Sökning: "mesencephalic"

Visar resultat 21 - 25 av 37 avhandlingar innehållade ordet mesencephalic.

1. 21. CELL REPLACEMENT THERAPY FOR PARKINSON’S DISEASE: The importance of neuronal subtype, cell source and connectivity for functional recovery

   Författare :Shane Grealish; Neurobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mouse behaviour; 6-hydroxydopamine; human embryonic stem cells; fetal tissue; connectivity; midbrain dopamine neuron subtype; cell transplantation; Parkinson’s disease;

   Sammanfattning : Parkinson’s disease (PD) is a neurodegenerative disorder characterised by motor deficits such as slowness in movement, difficulty in initiating movement and tremor at rest. The cause of these motor symptoms is the selective loss of mesencephalic dopaminergic (mesDA) neurons, located in the substantia nigra (SN). LÄS MER

3. 22. Neural crest in development and repair

   Författare :Jorge Benjamín Aquino; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : This thesis is focused on several aspects of neural crest biology, largely related to two main issues: 1) understanding its mechanisms of migration and 2) analyzing the potential of neural crest stem cells or their derivatives for nervous system repair. If repair is the aim, knowledge of both timing and events leading to axonal degeneration is required in order to block it and/or increase regeneration outcome. LÄS MER

4. 23. Neural circuits engaged in mastication and orofacial nociception

   Författare :Tuija Athanassiadis; K-G Westberg; Sten Grillner; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rhythmical jaw movements; central pattern generator; trigeminal system; rabbit; Rat; c-Fos; nociceptors; muscle pain; muscle spindle afferents; glutamate; Neurophysiology; Neurofysiologi; fysiologi; Physiology;

   Sammanfattning : A deeper understanding of both movement control and the effects of nociceptor inputs on our motor systems is critical for proper clinical diagnosis of musculo-skeletal dysfunctions and for development of novel rehabilitation schemes. In the jaw system, masticatory movements are produced by a central pattern generator (CPG) located in the brainstem. LÄS MER

5. 24. Interaction between nerve fiber formation and astrocytes

   Författare :Sanazalsadat Hashemian; Ingrid Strömberg; Elisabet Åkesson; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dopamine; nerve fiber outgrowth; astrocytes; ventral mesencephalon; spinal cord; CSPG; CD47;

   Sammanfattning : Parkinson’s disease, the second most common neurodegenerative disorder,is characterized by loss of nigrostriatal dopaminergic neurons. To date,there is no defined cause and cure for the disease. An ideal treatmentstrategy is to replace the lost neurons by transplanting fetal dopaminergicneurons to the brain of parkinsonian patients. LÄS MER

7. 25. On the influence of glia on neurite outgrowth from dopamine neurons in the nigrostriatal system

   Författare :Malin Saga Johansson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Dopamine; glia; astrocytes; olfactory ensheathing cells; development; ni-grostriatal; mesencephalon; Parkinson s disease; 6-hydroxydopamine;

   Sammanfattning : Interactions between glial cells and neurons are important during fetal development, in the maintenance of the normal functions in tile central nervous system (CNS), arid in response to injuries or diseases. Some of die motor disturbances in Parkinson's disease, a neurodegenerative disorder where one of the hallmarks is degeneration of dopamine (DA) neurons and concomitant depletion of DA in striatum, can be alleviated by intrastriatal grafting of embryonic DA tissue. LÄS MER