Sökning: "fetal tissue"

Visar resultat 1 - 5 av 140 avhandlingar innehållade orden fetal tissue.

  1. 1. Fetal hematopoietic cells in early gestation : aspects in view of fetal transplantation

    Författare :Sverker Ek; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Fetal stem cells; fetal liver; fetal hematopoiesis; immunological ontogeny; fetal transplantation; cytokines; CD34 enrichment;

    Sammanfattning : The fetus as a patient is a challenge. There are opportunities for early, sometimes life-saving procedures or there may be advantages in prenatal rather than postnatal intervention. This is the case in fetal hematopoietic cell (FHC) transplantation where conditions caused by a defect in blood cell formation may be life-threatening to the fetus. LÄS MER

  3. 2. CELL REPLACEMENT THERAPY FOR PARKINSON’S DISEASE: The importance of neuronal subtype, cell source and connectivity for functional recovery

    Författare :Shane Grealish; Neurobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mouse behaviour; 6-hydroxydopamine; human embryonic stem cells; fetal tissue; connectivity; midbrain dopamine neuron subtype; cell transplantation; Parkinson’s disease;

    Sammanfattning : Parkinson’s disease (PD) is a neurodegenerative disorder characterised by motor deficits such as slowness in movement, difficulty in initiating movement and tremor at rest. The cause of these motor symptoms is the selective loss of mesencephalic dopaminergic (mesDA) neurons, located in the substantia nigra (SN). LÄS MER

  4. 3. Aspects of the human enteric nervous system : A study of the normal development and of Hirschsprung's disease

    Författare :Tomas Wester; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; enteric nervous system; Hirschsprung s disease; intestinal neuronal dysplasia; neuron density; nitric oxide; bcl-2; interstitial cells of Cajal; c-kit; human; fetal; development; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

    Sammanfattning : Thirty patients with Hirschsprung's disease (HD) who underwent Rehbein's anterior resection, using a circular stapler to perform the anastomosis, were evaluated retrospectively. The postoperative complication rate and long-term functional outcome were similar to those reported by other investigators using the same and other techniques. LÄS MER

  5. 4. Hematopoietic stem and progenitor cells and potentials for application in fetal cell replacement therapy

    Författare :Karina Liuba; Lund Obstetrik och gynekologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; in utero hematopoietic cell transplantation; hematopoietic stem cell; multipotent progenitor; fetal therapy; heterotypic cell fusion;

    Sammanfattning : Fetal cell replacement therapy or in utero hematopoietic cell transplantation (IUHCT) is proposed as a non-myeloablative alternative to bone marrow transplantation (BMT) for a number of inborn immunologic, hematologic and metabolic disorders. IUHCT represents the method through which variable amounts of natural or genetically modified hematopoietic cells can be transferred to the fetal recipient in hope of correcting the disorder and preventing postnatal permanent organ damage. LÄS MER

  7. 5. Fetal programming and parent-of-origin effects of type 2 diabetes and insulin secretion

    Författare :Gad Hatem; diabetes och endokrinologi Genomik; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Type 2 Diabetes; fetal programming; parent-of-origin effects; transcriptopmics;

    Sammanfattning : Abstract Type 2 diabetes mellitus (T2DM) is a heterogeneous and a complex disease defined by hyperglycemia. Thepancreas and its islets are central for glucose homeostasis and healthy adipose tissue. In turn, lipid levels in the bloodare crucial for glucose level stability. LÄS MER