Sökning: "macropinocytosis"

Visar resultat 6 - 10 av 16 avhandlingar innehållade ordet macropinocytosis.

  1. 6. Toll-like receptor activation induced changes in dendritic cells

    Författare :Oscar Hammarfjord; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Dendritic cells (DC) are professional antigen-presenting cells that act as a “bridge” between innate and adaptive immunity by the induction and subsequent orchestration of immune responses. The ligation of Toll-like receptors (TLR) and other innate receptors on DC determines their immune-stimulating capacity. LÄS MER

  3. 7. Internalization mechanisms of cell-penetrating peptides : Structure-activity relationships, cellular distribution and membrane toxicity studies

    Författare :Mats Hansen; Ülo Langel; Mark Lindsay; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell-penetrating peptides; mechanisms; toxicity; structure-activity relationship; Neurochemistry; Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

    Sammanfattning : Transport of substances with pharmaceutical potential over the plasma membrane has been pushed a great step forward with the discovery of short cationic polypeptides, known as cell-penetrating peptides (CPP). Since then, the internalization mechanism and cargo delivery properties of CPPs has been extensively studied. LÄS MER

  4. 8. Biophysical studies of membrane interacting peptides derived from viral and Prion proteins

    Författare :Kamila Oglęcka; Astrid Gräslund; Stephen White; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Prion peptides; Doppel peptide; Influenza fusion peptides; peptide-membrane interactions; translocation; linear dichroism; circular dichroism; Biophysics; Biofysik; Biophysics; biofysik;

    Sammanfattning : This thesis focuses on peptides derived from the Prion, Doppel and Influenza haemagglutinin proteins in the context of bilayer interactions with model membranes and live cells. The studies involve spectroscopic techniques like fluorescence, fluorescence correlation spectroscopy (FCS), circular and linear dichroism (CD and LD), confocal fluorescence microscopy and NMR. LÄS MER

  5. 9. Effects of Microparticulate Drug Delivery Systems : Tissue Responses and Transcellular Transport

    Författare :Eva Ragnarsson; Per Artursson; Lucia Lazorova; David Brayden; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; microparticles; vaccine; pDNA vaccine; cationic polymer; gene expression analysis DNA array ; Caco-2; follicle-associated epithelium FAE ; M cell; transcytosis; Yersinia pseudotuberculosis; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

    Sammanfattning : Over the past decade, the development of macromolecular drugs based on peptides, proteins and nucleic acids has increased the interest in microparticulate drug delivery, i.e., the delivery of drug systems in the nanometer and micrometer ranges. LÄS MER

  7. 10. Cell-Penetrating Penetratin Peptides - Mechanistic Studies on Uptake Pathways and DNA Delivery Efficiency

    Författare :Helene Åmand; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Plasma membrane vesicle; Lysine; Stimulated endocytosis; Gene delivery; Cell surface affinity; Penetratin; Cell-penetrating peptide; Cysteine; Uptake; Arginine;

    Sammanfattning : Delivery of gene-targeted drugs is limited by the inherently poor capacity of nucleic acids to overcome the membrane barrier of the cell, and development of vectors that can promote uptake is therefore crucial. Cell penetrating peptides (CPPs) have emerged as promising vector candidates due to their ability to deliver a wide range of macromolecular cargos into cells. LÄS MER