Sökning: "lymphocyte subsets"

Visar resultat 21 - 25 av 62 avhandlingar innehållade orden lymphocyte subsets.

1. 21. Mechanisms of leukemia-induced immunosuppression

   Författare :Johan Aurelius; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute myeloid leukemia; Immunosuppression; Immunotherapy; Reactive oxygen species; PARP-1; NK cells; T cells;

   Sammanfattning : This thesis aimed to define the role of reactive oxygen species (ROS), produced by the NADPH oxidase of myeloid cells, in the regulation of lymphocyte function with focus on ROS-induced dysfunction of natural killer (NK) cells and T lymphocytes in myeloid leukemia. In Paper I, a novel mechanism is presented by which specifically activated T lymphocytes evade inactivation by ROS after antigen presentation. LÄS MER

3. 22. Regulation of immunity in Multiple Sclerosis : CD4+ T cells and the influence of natalizumab

   Författare :Måns Edström; Jan Ernerudh; Maria Jenmalm; Charlotte Dahle; Finn Sellebjerg; Örebro universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Multiple sclerosis (MS) is an autoimmune disease targeting the central nervous system (CNS) and the most common neurological cause of disability in young adults. In most cases, the disease course is characterised by the cycling of relapses and remissions, so called relapsing-remitting MS (RR-MS). LÄS MER

4. 23. Immunological Mechanisms and Natalizumab Treatment in Multiple Sclerosis : Studies on lymphocytes, inflammatory markers and magnetic resonance spectroscopy

   Författare :Johan Mellergård; Magnus Vrethem; Jan Ernerudh; Charlotte Dahle; Sten Fredrikson; Linköpings universitet; []
   Nyckelord :;

   Sammanfattning : Background: Multiple sclerosis (MS) is a chronic inflammatory, demyelinating disease of the central nervous system (CNS), and a frequent cause of neurological disability among young adults. In addition to focal inflammatory demyelinated lesions, diffuse white matter pathology as well as a neurodegenerative component with accumulating axonal damage and gliosis have been demonstrated and contribute to MS disease characteristics. LÄS MER

5. 24. New Aspects of Alveolar Adaptive Immune Responses in COPD

   Författare :Michiko Mori; Luftvägsinflammation; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Chronic obstructive pulmonary disease (COPD) is characterised by a chronic inflammation in conducting airways and the alveolar parenchyma. The inflammation, which is a consequence of inhalation of noxious gases like tobacco smoke, has traditionally been thought to be driven by innate immune responses. LÄS MER

7. 25. T cells in chronic obstructive pulmonary disease

   Författare :Ester Roos-Engstrand; Anders Blomberg; Anders Bucht; Annelie F Behndig; Magnus Sköld; Claes-Göran Löfdahl; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; airway epithelium; bronchoscopy; bronchoalveolar lavage; endobronchial mucosal biopsies; inflammation; flow cytometry; T lymphocytes; CD25; CD127; FoxP3; Lung diseases; Lungsjukdomar; lungmedicin; Lung Medicine;

   Sammanfattning : Background: Tobacco smoking is the main cause of chronic obstructive pulmonary disease, COPD, but the mechanisms by which cigarette smoke induces COPD are still elusive. T lymphocytes have been implicated in the pathogenesis of the disease, but their role in the airway inflammation in COPD is not fully understood. LÄS MER