Sökning: "lateral gene transfer"

Visar resultat 6 - 10 av 16 avhandlingar innehållade orden lateral gene transfer.

  1. 6. Drug discovery against leishmaniasis : Bio- and chemoinformatic guided strategies for target evaluation and hit identification

    Författare :Elisabet Vikeved; UCM Alsmark; Christian Sköld; David Horn; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Leishmaniasis; Drug discovery; Lateral gene transfer; Comparative genomics; Virtual screening; Target fishing; Marine natural products;

    Sammanfattning : Leishmaniasis is a neglected tropical disease mainly affecting poor people in developing countries. It is caused by infections of flagellated protozoa belonging to genus Leishmania. The few available drugs are associated with problems such as low effectiveness, severe side effects and resistance development. LÄS MER

  3. 7. Stolen genes, a shortcut to success : Evolution of metabolic and detoxification capacities in Diplomonads

    Författare :Alejandro Jimenez-Gonzalez; Jan Andersson; Thomas A. Richards; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Diplomonads; Parasitism; Evolutionary Genomics; Metabolism; Lateral Gene Transfer;

    Sammanfattning : Parasites do not represent a single evolutionary lineage meaning that they have evolved several times. The changes that parasites have undergone to adapt to such a lifestyle are not entirely understood. LÄS MER

  4. 8. Reconciling gene family evolution and species evolution

    Författare :Joel Sjöstrand; Jens Lagergren; Nicolas Lartillot; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Computational biology; Bioinformatics; Phylogenetics; Phylogenomics; Comparative genomics; Evolutionary biology; datalogi; Computer Science;

    Sammanfattning : Species evolution can often be adequately described with a phylogenetic tree. Interestingly, this is the case also for the evolution of homologous genes; a gene in an ancestral species may – through gene duplication, gene loss, lateral gene transfer (LGT), and speciation events – give rise to a gene family distributed across contemporaneous species. LÄS MER

  5. 9. Probabilistic Models for Species Tree Inference and Orthology Analysis

    Författare :Ikram Ullah; Jens Lagergren; Arndt von Haeseler; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; phylogenetics; phylogenomics; gene tree; species tree; expectation maximization; mixture model; dynamic programming; markov chain monte carlo; PrIME; JPrIME; Datalogi; Computer Science;

    Sammanfattning : A phylogenetic tree is used to model gene evolution and species evolution using molecular sequence data. For artifactual and biological reasons, a gene tree may differ from a species tree, a phenomenon known as gene tree-species tree incongruence. Assuming the presence of one or more evolutionary events, e.g. LÄS MER

  7. 10. Integration of Arabidopsis and poplar model systems to elucidate gene function during wood formation

    Författare :Ellinor Edvardsson; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Sammanfattning : Wood is an essential raw material being used for a number of different applications including construction, pulp and paper production and as a source of biomass for bioenergy generation. The increasing number of sequenced plant genomes provides powerful tools to evaluate plant gene function. LÄS MER