Sökning: "läkemedelsutveckling"

Visar resultat 11 - 15 av 25 avhandlingar innehållade ordet läkemedelsutveckling.

  1. 11. From Static Structures to Free Energy Landscapes: Characterizing Conformational Transitions in Biological Macromolecules

    Författare :Cathrine Bergh; Erik Lindahl; Gerhard Hummer; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein conformational transitions; molecular dynamics simulations; statistical mechanics; ion channels; Proteinkonformationsövergångar; molekyldynamiksimuleringar; statistisk mekanik; jonkanaler;

    Sammanfattning : To be alive means to temporarily counteract the fundamental dispersive driving force described by the second law of thermodynamics, eventually leading all systems to decay and disorder. In cells, this task is partly carried out by proteins - small specialized molecular machines that utilize free energy to maintain the proper functioning of the cell. LÄS MER

  3. 12. Utilizing Biopolymers in 3D Tumor Modeling and Tumor Diagnosis

    Författare :Negar Abbasi Aval; Torbjörn Pettersson; Aman Russom; Maria Tenje; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 3D tumor modeling; Spheroids; Cellulose Nano Fibrils; Layer by Layer; Extracellular matrix; Circulating Tumor Capturing; Pancreatic ductal adenocarcinoma PDAC ; 3D-tumörmodellering; Sfärer; Cellulosa; Lager-på-lager; Extracellulärmatris; Infångning av cirkulerande tumörceller; Mänskliga Duktala Adenocarcinom-Hepatocyter; Fiber- och polymervetenskap; Fibre and Polymer Science;

    Sammanfattning : Cancer represents a significant global public health challenge and ranks as the second mostcommon cause of death in the United States. The onset of cancer entails an initial phasewhere cells lose their polarity and disconnect from the normal basement membrane, allowingthem to form distinct three-dimensional (3D) configurations that interact with adjacent cellsand the surrounding microenvironment. LÄS MER

  4. 13. Combining Evolution and Physics through Machine Learning to Decipher Molecular Mechanisms

    Författare :Darko Mitrovic; Lucie Delemotte; Gerhard Hummer; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular Dynamics Simulation; Evolution; Enhanced Sampling; Machine Learning; Molecular Mechanism; Molekyldynamiksimuleringar; Evolution; Accelererad utforskning; Maskininlärning; Molekylära mekanismer; Biologisk fysik; Biological Physics;

    Sammanfattning : From E.coli to elephants, the cells of all living organisms are surrounded by a near impenetrable wall of lipids. The windows through the walls are membrane proteins - receptors, transporters and channels that confer communication, information and metabolites through the membrane. LÄS MER

  5. 14. Spider Silk Nanostructuring and its Applications for Tissue Engineering

    Författare :Linnea Gustafsson; Wouter van der Wijngaart; David Kaplan; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; recombinant spider silk; nanostructures; microstrucutres; nanowires; nanochains; nanodisks; nanomembranes; tissue engineering; in-vitro models; medical technology; health technology; nanomedicine; rekombinant spindelsilke; nanostrukturer; mikrostrukturer; nanotrådar; nanokedjor; nanodiskar; nanomembran; vävnadsteknik; in vitro-modeller; medicinsk teknik; hälsoteknik; nanomedicin; Electrical Engineering; Elektro- och systemteknik;

    Sammanfattning : This thesis introduces new ways to produce micro-and nanostructures of recombinant spider silk and explores ways to characterize their topography, mechanical properties, cell compatibility, and permeability. The suitability of the formed structures for applications within tissue engineering, primarily in vitro tissue modeling, is also investigated. LÄS MER

  7. 15. Acetals - Exploring reactivity for improved carbohydrate synthesis

    Författare :Markus Ohlin; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : In my research, I have explored various aspects of acetals and their reactivity. Acetals have a central role in carbohydrate chemistry as an inherent functionality and as versatile protecting groups. The first part of the thesis summarizes results on regioselective reductive openings of benzylidene acetals. LÄS MER