Sökning: "klinisk farmakologi"

Visar resultat 6 - 10 av 317 avhandlingar innehållade orden klinisk farmakologi.

  1. 6. Methodological aspects and usefulness of Quantitative Sensory Testing in early small fiber polyneuropathy a clinical study in Swedish hereditary transthyretin amyloidosis patients

    Detta är en avhandling från Umeå : Umeå universitet

    Författare :Victoria Heldestad; Umeå universitet.; Umeå universitet.; [2011]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amyloidosis; cold thresholds; heart rate variability; method-of-limits; quantitative sensory testing; transthyretine; warm thresholds; Clinical Neurophysiology; klinisk neurofysiologi;

    Sammanfattning : Generalised polyneuropathy (PNP) is a common cause to neurological impairment, and may be an early symptom of a severe systemic disease. One such illness is hereditary transthyretin (TTR) amyloidosis (ATTR), a progressive fatal disorder caused by a mutation on the TTR gene. LÄS MER

  2. 7. Spontaneous reporting of adverse drug reactions Possibilities and limitations

    Detta är en avhandling från Umeå : Farmakologi och klinisk neurovetenskap

    Författare :Martin Bäckström; Umeå universitet.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; adverse drug reactions; spontaneous reporting; metamizole; general practitioners; hospital physicians; under-reporting; economical inducement; nurses.; Farmakologi; MEDICINE Physiology and pharmacology Pharmacological research; MEDICIN Fysiologi och farmakologi Farmakologisk forskning; klinisk farmakologi; Clinical Pharmacology;

    Sammanfattning : Adverse drug reactions (ADRs) constitute a major problem in society and in drug therapy. They are a common cause of short-term hospitalization, prolonged hospitalization and death. Spontaneous reporting of ADRs remains one the most effective methods for detecting new and serious drug reactions. LÄS MER

  3. 8. Neurotoxicity of β-lactam antibiotics experimental kinetic and neurophysiological studies

    Detta är en avhandling från Umeå : Umeå universitet

    Författare :Silvia E. Schliamser; Umeå universitet.; [1988]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; benzylpenicillin; blood-brain barrier; ß-lactam antibiotics; CSF; CNS; EEG; imipenem cilastatin; FCE 22101; meningitis; neurotoxicity of; silent-second; thiopental; transport system; uraemia;

    Sammanfattning : The neurotoxic potential of intravenous administered benzylpenicillin (BPC) was studied in rabbits with intact blood-CNS barriers and rabbits with experimental E. coli meningitis. At onset of epileptogenic EEG activity or seizures, serum, CSF and brain tissue were collected for assay of BPC. LÄS MER

  4. 9. Misfolded superoxide dismutase-1 in amyotrophic lateral sclerosis

    Detta är en avhandling från Umeå : Umeå universitet

    Författare :Per Zetterström; Umeå universitet.; Umeå universitet.; Umeå universitet.; [2011]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALS; SOD1; protein misfolding; SOD1 conformation; disulfide-reduced; transgenic mice; cerebrospinal fluid; protein-protein interaction; antibodies; MEDICINE Chemistry Clinical chemistry; MEDICIN Kemi Klinisk kemi; Clinical Chemistry; klinisk kemi;

    Sammanfattning : Amyotrophic lateral sclerosis (ALS) is a disease in which the motor neurons die in a progressive manner, leading to paralysis and muscle wasting. ALS is always fatal, usually through respiratory failure when the disease reaches muscles needed for breathing. Most cases are sporadic, but approximately 5–10% are familial. LÄS MER

  5. 10. Development of new methodology for therapeutic drug monitoringof thiopurine treatment

    Detta är en avhandling från Linköping : Linköping University Electronic Press

    Författare :Svante Vikingsson; Linköpings universitet.; Linköpings universitet.; [2012]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Thiopurines; mercaptopurine; thioguanine; azathioprine; crohn s disease; ulcertive colitis; HPLC; TGN;

    Sammanfattning : The three thiopurine drugs azathioprine (AZA), 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG) are used to treat several diseases, including inflammatory bowel disease (IBD). They are pro-drugs and are believed to act through the formation of thioguanine nucleotides (TGNs). LÄS MER