Sökning: "isotype"

Visar resultat 6 - 10 av 67 avhandlingar innehållade ordet isotype.

  1. 6. Antigens and antibodies involved in humoral immunity to plasmodium falciparum

    Författare :Mats Wahlgren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Malaria plasmodiidae cause more death and disease than any other known human pathogen. The parasite still threatens half of the world population {2.5 billion) and 300 million people are considered to become infected every year. LÄS MER

  3. 7. Targeting cytotoxic species in amyloid diseases

    Författare :Malin Lindhagen Persson; Anders Olofsson; Lars Tjernberg; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; Amyloid-beta; transthyretin; FAP; amyloid; cytotoxic species; oligomers; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : Amyloid diseases are a world-wide problem causing great human suffer and large economical costs. Although amyloid deposits, a common denominator in all amyloid disorders, are detrimental to the surrounding tissue, there is a poor correlation between total amyloid burden and clinical symptoms. LÄS MER

  4. 8. Studies of immunoglobulin light chains in rainbow trout (Oncorhynchus mykiss): new insight into the evolution of immunoglobulin genes

    Författare :Sirje Timmusk; Greg Warr; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Immunoglobulin genes; gene organization; evolution; comparative immunology; promoter; rainbow trout Oncorhynchus mykiss ; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; molekylär immunologi; Molecular Immunology;

    Sammanfattning : In this thesis, the structure and the expression of immunoglobulin (Ig) light chain genes were studied in rainbow trout and including an evolutionary perspective. A novel Ig light chain locus (IgL2) was identified and characterized. LÄS MER

  5. 9. Pathogenetic factors of importance for the development and progression of rheumatoid arthritis

    Författare :Heidi Kokkonen; Solbritt Rantapää-Dahlqvist; Dirkjan van Schaardenburg; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rheumatoid arthritis; cytokines; autoantibodies; isotypes; PTPN22; HLA-SE; reumatologi; rheumatology;

    Sammanfattning : Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation eventually leading to the destruction of cartilage and bone. The aetiopathogenesis is not completely understood, but previous studies have shown that the disease is multifactorial with genetic, environmental and hormonal factors involved. Immune cells, e. LÄS MER

  7. 10. Genetic regulation of autoimmunity in experimental neuroinflammation

    Författare :Sevasti Flytzani; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Multiple sclerosis (MS) is a chronic inflammatory disease that affects the central nervous system causing axonal demyelination and leads to significant disabilities. MS affects mainly young adults and incidence of disease in Sweden is around 600 new cases/year. LÄS MER