Sökning: "Lars Tjernberg"

Hittade 4 avhandlingar innehållade orden Lars Tjernberg.

  1. 1. Molecular basis and pharmacological implications of Alzheimer amyloid ß-peptide fibril formation

    Författare :Lars Tjernberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Alzheimer s disease; amyloid; fibrils; inhibitor; protease resistance; electron microscopy; fluorescence correlation spectroscopy.;

    Sammanfattning : Alzheimer's disease is a progressive neurodegenerative disease, mostly affecting elderly. The invariable deposition of protease-resistant fibrils of Alzheimer amyloid ß-peptide (Aß) in the parenchyma and blood vessels of the brain is a central event. LÄS MER

  3. 2. Neuron-to-neuron propagation of neurodegenerative proteins; relation to degradative systems

    Författare :Jakob Domert; Martin Hallbeck; Jan Marcusson; Lars Tjernberg; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell-to-cell transfer; beta-amyloid; Alzheimer s disease; degradation; proteasome; alpha-synuclein; Parkinson s disease; high throughput screening model;

    Sammanfattning : Alzheimer’s disease (AD) and Parkinson’s disease (PD) are defined by neurodegeneration and accumulations of misfolded proteins that spread through the brain in a well characterized manner. In AD these accumulations consist mainly of β-amyloid (Aβ) and tau, while in PD, α-synuclein (α-syn) make up the characteristic lewy pathology. LÄS MER

  4. 3. Neoehrlichia mikurensis in Sweden : An emerging tick-borne human pathogen

    Författare :Lisa Labbé Sandelin; Björn Olsen; Jonas Waldenström; Per-Eric Lindgren; Ivar Tjernberg; Lars Hagberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neoehrlichia; Tick-borne Infections; Transfusion-transmitted infections; Bacterial Zoonotic infections; Blood Donors; Immunosuppression; Infectious Diseases; Emerging; Blood Safety; Bird Migration; Infektionssjukdomar; Infectious Diseases;

    Sammanfattning : Neoehrlichia mikurensis is an emerging tick-borne human pathogen, causing neoehrlichiosis in immunosuppressed and immunocompetent individuals. It targets the vascular endothelium, leading to thromboembolic and vascular events, but can also pass without symptoms. LÄS MER

  5. 4. Targeting cytotoxic species in amyloid diseases

    Författare :Malin Lindhagen Persson; Anders Olofsson; Lars Tjernberg; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; Amyloid-beta; transthyretin; FAP; amyloid; cytotoxic species; oligomers; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : Amyloid diseases are a world-wide problem causing great human suffer and large economical costs. Although amyloid deposits, a common denominator in all amyloid disorders, are detrimental to the surrounding tissue, there is a poor correlation between total amyloid burden and clinical symptoms. LÄS MER