Sökning: "isotypes"

Visar resultat 1 - 5 av 37 avhandlingar innehållade ordet isotypes.

  1. 1. Pathogenetic factors of importance for the development and progression of rheumatoid arthritis

    Författare :Heidi Kokkonen; Solbritt Rantapää-Dahlqvist; Dirkjan van Schaardenburg; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rheumatoid arthritis; cytokines; autoantibodies; isotypes; PTPN22; HLA-SE; reumatologi; rheumatology;

    Sammanfattning : Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation eventually leading to the destruction of cartilage and bone. The aetiopathogenesis is not completely understood, but previous studies have shown that the disease is multifactorial with genetic, environmental and hormonal factors involved. Immune cells, e. LÄS MER

  3. 2. Rheumatoid Arthritis in a 10-Year Perspective, Outcome for Patients Followed from Early Disease

    Författare :Elisabet Lindqvist; Reumatologi och molekylär skelettbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reumatologi; muskelsystem; rheumatology locomotion; Skelett; COMP; Skeleton; muscle system; Anti-IL-1alpha; Anti-CCP; Rheumatoid factor isotypes; Mortality; Radiographic progression; Joint damage; Disease activity; HAQ; SOFI; Disability; Prognosis; Rheumatoid arthritis; Outcome;

    Sammanfattning : Rheumatoid arthritis (RA) is characterized by persistent inflammation, progressive joint damage and disability. This thesis describes the outcome after 10 years in a cohort of 183 RA patients (116 women, 67 men) recruited 1985-89. The mean age was 51 years and symptom duration 11 months at inclusion. LÄS MER

  4. 3. The rise and fall of IgE

    Författare :Molly Vernersson; Rikard Holmdahl; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Immunoglobulin; IgE; evolution; atopic allergy; vaccine; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; Molecular Immunology; molekylär immunologi;

    Sammanfattning : Immunoglobulin E (IgE) occurs exclusively in mammals and is one of five immunoglobulin (Ig) classes found in man. Unlike other isotypes, IgE is best known for its pathological effects, whereas its physiological role remains somewhat elusive. LÄS MER

  5. 4. Immunoglobulin-Fc receptor interactions in cytotoxicity and phagocytosis mediated by lymphocytes and monocytes

    Författare :Christer Öhlander; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Antibody dependent cellular cytotoxicity (ADCC) and phagocytosis mediated by lymphocytes and monocytes depend on IgG-binding Fc receptors on the effector cells. Properties of the immunoglobulin-Fc receptor interactions of human lymphocytes and monocytes were investigated using 51Cr release assays for detection of cytolysis or phagocytosis of target erythrocytes. LÄS MER

  7. 5. Antigens and antibodies involved in humoral immunity to plasmodium falciparum

    Författare :Mats Wahlgren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Malaria plasmodiidae cause more death and disease than any other known human pathogen. The parasite still threatens half of the world population {2.5 billion) and 300 million people are considered to become infected every year. LÄS MER