Sökning: "islets of Langerhans"

Visar resultat 21 - 25 av 108 avhandlingar innehållade orden islets of Langerhans.

  1. 21. Quantification of gene expression in single cells

    Författare :Martin Bengtsson; Islet cell physiology; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; Biomedical sciences; Biomedicinska vetenskaper; quantitative gene expression analysis; single cell PCR; islets of Langerhans;

    Sammanfattning : Studies of apparently homogeneous cell populations and single cells often give highly divergent results. Cells exhibit varying responsiveness to stimuli and gene expression and they are in many aspects stochastic and unpredictable. We have developed a method to measure gene expression quantitatively in individual cells with real-time RT-PCR. LÄS MER

  3. 22. Studies of Innate and Adaptive Immunity in Islet Transplantation

    Författare :Maria Hårdstedt; Olle Korsgren; Bo Nilsson; Thierry Berney; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetes; islet transplantation; islets of Langerhans; xenotransplantation; nonhuman primate; blood; whole blood model; innate immunity; adaptive immunity; IBMIR; chemokines;

    Sammanfattning : Clinical islet transplantation is today an established alternative treatment for a selected group of type 1 diabetes patients. The predominant technique for transplantation is infusion of islets in the liver via the portal vein. LÄS MER

  4. 23. Properties of Endothelium and its Importance in Endogenous and Transplanted Islets of Langerhans

    Författare :Åsa Johansson; Per-Ola Carlsson; JanOve Sehlin; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; islet transplantation; endothelial cells; engraftment; beta cells; Diabetology; Diabetologi; Medical Cell Biology; medicinsk cellbiologi;

    Sammanfattning : Transplantation of insulin producing cells is currently the only cure for type 1 diabetes. However, even though the Edmonton protocol markedly increased the success rate of pancreatic islet transplantation, the long term insulin independence is still very poor. An adequate engraftment is critical for islet graft survival and function. LÄS MER

  5. 24. On macrophage contributions to tissue homeostasis : New insights on pancreas development and healing of ischemic injury

    Författare :Carmen Herrera Hidalgo; Mia Phillipson; Andrés Hidalgo; Uppsala universitet; []
    Nyckelord :macrophages; islets of Langerhans; β cell function; postnatal β cell maturation; hindlimb ischemia; blood flow regulation; mural cells; vessel pruning; diabetes mellitus; ischemic diseases;

    Sammanfattning : Besides providing host defence against innumerable threats, macrophages display additional key functions for preservation of tissue homeostasis. This thesis includes four studies that explore novel macrophage functions in both the development of islets of Langerhans and healing of ischemic injury in mice. LÄS MER

  7. 25. Studies of the Pancreas: Implications for Type 1 Diabetes Aetiology

    Författare :Peter Seiron; Oskar Skog; Michele Solimena; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pancreas; Type 1 Diabetes; Insulitis; Beta cells; Immunology; Tissue resident memory T cells; Islets of Langerhans; Endocrinology and Diabetology; Endokrinologi och Diabetologi; Immunologi; Immunology;

    Sammanfattning : Type 1 diabetes (T1D) is a disease of severe insulin deficiency through loss of β cells in the endocrine pancreas. The T1D dogma maintains that a precipitating event unleashes autoimmunity in at-risk individuals, often measured through autoantibodies against β cell antigens. LÄS MER