Sökning: "intrinsic and extrinsic"

Visar resultat 31 - 35 av 155 avhandlingar innehållade orden intrinsic and extrinsic.

1. 31. Cellular Effects of Cystatins

   Författare :Samar Hunaiti; Avdelningen för klinisk kemi och farmakologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cystatin C; Cystatin D; Galectin-1; Puncta assay; HoloMonitor; Cancer cells; Apoptosis; Cathepsin C;

   Sammanfattning : The exact cellular functions of cystatins are still unknown, and the molecular mechanism leading to their internalization into cells is not yet fully understood. Commonly the cystatins are known to inhibit human lysosomal cysteine proteases (cysteine cathepsins) and it is supposed that this is their primary physiological role. LÄS MER

3. 32. Modeling Human Hematopoiesis Using the CRISPR/Cas9 System

   Författare :Alexandra Bäckström; Avdelningen för molekylärmedicin och genterapi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoiesis; Hematopoietic stem and progenitor cells; HSC regulation; CRISPR Cas9; Gene editing;

   Sammanfattning : Hematopoietic stem cells (HSCs) have the ability to self-renew and to give rise to all blood cells of the different lineages, and are thereby responsible for the replenishment of blood cells throughout life. These cells are tightly regulated by extrinsic and intrinsic regulators, such as signals from the bone marrow microenvironment, complex transcription factor networks and epigenetic regulators. LÄS MER

4. 33. Magnetodynamics in Spin Valves and Magnetic Tunnel Junctions with Perpendicular and Tilted Anisotropies

   Författare :Quang Tuan Le; Johan Åkerman; Erik Wahlström; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; perpendicular magnetic anisotropy; tilted-polarizer; spintronics; STT; MTJ; pseudospin-valve; STO; ST-FMR; magnonics; magnetic droplet; droplet nucleation; droplet annihilation; vinkelrät magnetisk anisotropi; lutande polarisator; spinntronik; STT; MTJ; pseudospinnventil; STO; ST-FMR; magnonics; magnetisk droppe; nukleering av droppe; anihilering av droppe.; Physics; Fysik;

   Sammanfattning : Spin-torque transfer (STT) effects have brought spintronics ever closer to practical electronic applications, such as MRAM and active broadband microwave spin-torque oscillator (STO), and have emerged as an increasingly attractive field of research in spin dynamics. Utilizing materials with perpendicular magnetic anisotropy (PMA) in such applications offers several great advantages such as low-current, low-field operation combined with high thermal stability. LÄS MER

5. 34. First principles study of tungsten-based alloys: From defect thermodynamics to phase diagrams

   Författare :Leili Gharaee; Chalmers tekniska högskola; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; structural materials; first-principles calculations.; point defects; tungsten alloys; irradiation;

   Sammanfattning : Nuclear fusion is a very attractive option for energy production as it is clean, safe and efficient. The major obstacle in construction of fusion power plants is the development of materials that can tolerate the extreme operational condition especially high-energy neutron flux. LÄS MER

7. 35. Characterization of human myeloid progenitors and their differentiation

   Författare :Louise Edvardsson; Avdelningen för hematologi och transfusionsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; extracellular fluids; Haematology; Medicin människa och djur ; thrombopoietin receptor; hematopoiesis; transcription factors; growth factor receptors; human myeloid progenitors; Hematologi; extracellulära vätskor;

   Sammanfattning : All hematopoietic cells are derived from the hematopoietic stem cells (HSCs) in a continuous and dynamic process, regulated by a network of transcription factors in different combinations and extrinsic signals from growth factors (GFs) and other factors in the microenvironment. In the initial stages of hematopoiesis HSCs differentiate to progenitor cells with gradually more restricted lineage potential and according to the most accepted model the first restriction in developmental potential results in commitment to either the lymphoid or the myeloid branch, in the latter followed by commitment to the neutrophil/monocyte and erythrocyte/megakaryocyte lineages. LÄS MER