Sökning: "Gene editing"
Visar resultat 1 - 5 av 53 avhandlingar innehållade orden Gene editing.
1. The diverse functions of the ADAR enzymes : Editing and editing-independent effects on gene expression
Sammanfattning : The adenosine deaminase acting on RNA (ADAR) family of enzymes consists of three members (ADAR1-3). These enzymes are responsible for the deamination of adenosine into inosine in double-stranded RNA, one of the most common RNA modifications in mammals. LÄS MER
2. Precision mapping of gene expression and proteins in the brain using gene editing and barcoded viral vectors
Sammanfattning : The human brain is a masterpiece of intricate design and impeccable functionality. It serves as the ultimate command center for our thoughts, sensations, and actions, which define our very existence. LÄS MER
3. From GWAS to gene : Zebrafish as a model system for large-scale studies of obesity and comorbidities
Sammanfattning : Obesity increases the risk of developing comorbidities such as cardiovascular and metabolic diseases. However, not all obese individuals develop comorbidities, and those that do not are referred to as “metabolically healthy obesity” individuals. LÄS MER
4. Regulation of RNA Editing : The impact of inosine on the neuronal transcriptome
Sammanfattning : The transcriptome of the mammalian brain is extensively modified by adenosine to inosine (A-to-I) nucleotide conversion by two adenosine deaminases (ADAR1 and ADAR2). As adenosine and inosine have different base pairing properties, A-to-I RNA editing shapes the functional output of both coding and non-coding RNAs (ncRNAs) in the brain. LÄS MER
5. Understanding Cancer Mutations by Genome Editing
Sammanfattning : Mutational analyses of cancer genomes have identified novel candidate cancer genes with hitherto unknown function in cancer. To enable phenotyping of mutations in such genes, we have developed a scalable technology for gene knock-in and knock-out in human somatic cells based on recombination-mediated construct generation and a computational tool to design gene targeting constructs. LÄS MER