Sökning: "human homolog"

Visar resultat 16 - 20 av 64 avhandlingar innehållade orden human homolog.

  1. 16. The Identification and Characterisation of LRIG Gene Family and Its Expression in Astrocytic Tumours

    Författare :Dongsheng Guo; Tomas Ekström; Umeå universitet; []
    Nyckelord :astrocytoma; brain; EGFR; LRIG; leucine-rich repeat; real-time RT-PCR; onkologi; Oncology;

    Sammanfattning : Gliomas are the most common primary brain tumours, and their capacity to invade surrounding normal brain prevents complete removal of the tumour. Malignant glioma has still a poor prognosis. However, with the rapid development of molecular biology our understanding about glioma has increased dramatically. LÄS MER

  3. 17. Structural and functional studies of nutrient and drug uptake systems

    Författare :Fatma Guettou; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Orally ingested nutrients and drugs are selectively absorbed from our small intestines into the bloodstream through various membrane-integrated transporters. The present study focuses mainly on a specific absorption route, namely the proton dependent oligopeptide transporters (POTs). LÄS MER

  4. 18. The role of smooth muscle cells in calcification of atherosclerotic plaques

    Författare :Till Seime; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Calcification (CALC) is a predominant feature of late-stage cardiovascular disease (CVD) but responsible mechanisms and its contribution to the risk of clinical events remain unclear. Formation of highly mineralized extracellular matrix (ECM) leads to progressive aortic valve stenosis (AVS) and has been identified as a surrogate marker for atherosclerotic disease burden. LÄS MER

  5. 19. Cell Membrane Homeostasis in Mammals - The roles of ADIPOR2 and TLCD1 & 2

    Författare :Henrik Palmgren; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Membrane lipids; Membrane fluidity; Membrane homeostasis; Dietary lipids; Phospholipids; Genetics; Lipotoxicity; Lipidomics; ADIPOR2; TLCD1; TLCD2;

    Sammanfattning : Ten nanometers. That is the approximate thickness of the plasma membrane that separates the extracellular space from the entire cellular machinery. An asymmetrical bilayer consisting of predominantly phospholipids in which proteins and carbohydrates are anchored and exert their function. LÄS MER

  7. 20. The Path to Destruction : Understanding the mechanism and regulation of proteasomal degradation

    Författare :Anne Beskow; Patrick Young; Ylva Engström; Bernat Crosas; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Proteasome; ubiquitin; p97; Cnc-C; transcription factors; Nrf1; Nrf2; Molecular Biology; molekylärbiologi;

    Sammanfattning : A majority of intracellular proteins are degraded by the ubiquitin proteasome system (UPS). In this thesis, both the mechanism of the degradation and the regulation of UPS have been investigated. The importance of the p97 ATPase for proteasomal degradation of cytosolic substrates was examined. LÄS MER