Sökning: "homologous recombination"

Visar resultat 36 - 40 av 90 avhandlingar innehållade orden homologous recombination.

1. 36. Small Cajal body-associated RNA 2 and RNA-binding protein WRAP53β in DNA repair and Hoyeraal-Hreidarsson syndrome

   Författare :Sofie Bergstrand; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The DNA in our cells can be damaged through many different mechanisms and correct repair of DNA lesions is of utmost importance to ensure genomic integrity and prevent alteration in the genetic code contributing to diseases such as cancer, neurodegenerative disorders and premature aging. Non-coding RNAs were for a long time considered as non-functional transcriptional byproducts. LÄS MER

3. 37. Studies of DNA repair strategies in response to complex DNA damages

   Författare :Ainars Bajinskis; Mats Harms-Ringdahl; Bo Stenerlöw; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ionizing radiation; complex DNA damage; indirect effect of radiation; dimethyl sulfoxide; molekylärgenetik; Molecular Genetics;

   Sammanfattning : The main aim of this thesis was to study the role of the indirect actions of γ-rays and α-particles on the complexity of primary DNA damages and the repair fidelity of major DNA repair pathways: non-homologous end joining (NHEJ), homologous recombination repair (HRR) and base excision repair (BER). The complexity of radiation-induced damages increases and the proximity between damages decreases with increasing LET due to formation of ionization clusters along the particle track. LÄS MER

4. 38. DNA double-strand break repair in ascomycetes

   Författare :Jiang Chen; Stefan Åström; Michael Lisby; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; utvecklingsbiologi; Developmental Biology;

   Sammanfattning : Nonhomologous end joining (NHEJ) and homologous recombination (HR) are two pathways for DNA double strand break (DSB) repair. We found that the NHEJ protein Nej1 interacted physically with the HR protein Srs2, which was dependent on phosphorylation of Nej1 by Dun1. Srs2 recruitment to a DSB partly relied on Nej1 and Dun1. LÄS MER

5. 39. Characterization of chromatin mobility upon DNA damage in Arabidopsis thaliana

   Författare :Anis Meschichi; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
   Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

   Sammanfattning : Plant cells are subject to high levels of DNA damage from dependence on sunlight for energy and the associated exposure to biotic and abiotic stresses. Double-strand breaks (DSBs) are a particularly deleterious type of DNA damage, potentially leading to chromosome rearrangements or loss of entire chromosome arms. LÄS MER

7. 40. Genome Evolution in Maternally Inherited Insect Endosymbionts

   Författare :Lisa Klasson; Siv Andersson; Jonas Sandström; George Weinstock; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biology; Biologi; Biology; Biologi;

   Sammanfattning : Symbiosis is a widely common phenomenon in nature and has undoubtedly contributed to the evolution of all organisms on earth. Symbiotic associations can be of varying character, such as parasitic or mutualistic, but all imply a close relationship. LÄS MER