Sökning: "homologous recombination"

Visar resultat 31 - 35 av 90 avhandlingar innehållade orden homologous recombination.

  1. 31. The exosome and the maintenance of genome integrity

    Författare :Judit Domingo Prim; Neus Visa; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The RNA exosome acts on different RNA substrates and plays important roles in RNA metabolism. The fact that short non-coding RNAs are involved in the DNA damage response led us to investigate whether the exosome plays a role in DNA repair. LÄS MER

  3. 32. Genome Evolution of Neurospora tetrasperma

    Författare :Yu Sun; Hanna Johannesson; Siv Andersson; Toni Gabaldon; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Neurospora tetrasperma; next-generation sequencing; introgression; intron; chromosomal inversion; codon usage; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik;

    Sammanfattning : In this thesis work, I have used a comparative genomics approach to study a fungal model organism, Neurospora tetrasperma. My specific focus has been on genomic introgression, intron evolution, chromosomal structural rearrangements and codon usage. LÄS MER

  4. 33. Allosteric control of ALC1-catalyzed nucleosome remodeling

    Författare :Laura C. Lehmann; Sebastian Deindl; Stefan D. Knight; Felix Müller-Planitz; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ALC1; CHD1L; ATP-dependent chromatin remodeling; nucleosome; allosteric regulation; autoinhibition; macro domain; PARP; ADP-ribosylation; DNA damage; acidic patch; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi;

    Sammanfattning : The genetic information of eukaryotic cells is packaged inside the nucleus as chromatin. This packaging restricts access to the DNA and therefore represents a barrier for processes such as DNA replication, repair, and gene expression. LÄS MER

  5. 34. Molecular analysis of protein complexes involved in pairing of mammalian chromosomes during meiosis

    Författare :Jeanette Pelttari Danielsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : How is the accuracy of chromosomal pairing and segregation processes in dividing meiotic cells assured? This is an important question as premature or erratic segregation of chromosomes can give rise to aneuploidy, which is the leading genetic cause of pregnancy loss in humans. Meiosis is a cell division process that produces genetically unique haploid gametes from diploid cells. LÄS MER

  7. 35. Evolutionary patterns and processes of bacteriophages, particularly P2-like phages

    Författare :Anders Nilsson; Siv Andersson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Genetics; genetik;

    Sammanfattning : DNA sequencing of structural genes of temperate P2-like prophages from isolates of Escherichia coli bacteria showed that the difference between these genes was very small. Separate phylogenetic analyses on the genes resulted in unresolved trees, caused by a high level of homologous recombination, which implied that homologous recombination is the most important source of new genetic variation for P2-like phages infecting E. LÄS MER