Sökning: "heterodimer"

Visar resultat 11 - 15 av 71 avhandlingar innehållade ordet heterodimer.

  1. 11. Microtubule structure and function as perturbed by electromagnetic fields

    Författare :Greger Hammarin; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; X-ray; microtubules; microwaves; structural biology;

    Sammanfattning : Frontlinjen för strukturbiologisk forskning ligger idag i att avbilda proteiner i rörelse. För att förstå hur proteiner fungerar rent strukturellt krävs avbildningsmetoder med en tid- och rums-upplösning anpassad för den specifika biologiska funktionen. LÄS MER

  3. 12. Molecular dissection of established and proposed members of the Op18/Stathmin family of tubulin binding proteins

    Författare :Kristoffer Brännström; Martin Gullberg; Fredrik Ivars; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Op18 Stathmin; Sm16; tubulin; microtubule; schistosoma mansoni; Molecular biology; Molekylärbiologi;

    Sammanfattning : My initial aim was a functional analysis of the conserved Op18/stathmin family of microtubule-regulators, which includes the ubiquitous cytosolic Op18 protein and the neural membrane-attached RB3 and SCG10 proteins. The solved X-ray structure has shown that these proteins form a complex with tubulin -heterodimers via two imperfect helical repeats, which result in two head-to-tail aligned heterodimers in a tandem-tubulin complex. LÄS MER

  4. 13. Biological Activities of Natural and Semi-Synthetic Pseudo-Guaianolides: Inhibition of Transcription Factors

    Författare :Rodrigo Villagomez; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; pseudo-guaianolides; sesquiterpene lactones; NF-κB;

    Sammanfattning : Damsin (1) is a natural sesquiterpene lactone (SL) isolated from Ambrosia arborescens Mill., a plant used in the Andes as antiinflammatory medicine. LÄS MER

  5. 14. New Paradigms in GPCR Drug Discovery : Structure Prediction and Design of Ligands with Tailored Properties

    Författare :Mariama Jaiteh; Jens Carlsson; David E Gloriam; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; G Protein-Coupled Receptor; Molecular Docking; Virtual Screening; Homology Modeling; Molecular Dynamics Simulation; Chemical Library; Functionally Selective Ligand; Polypharmacology; Dimerization; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Sammanfattning : G protein-coupled receptors (GPCRs) constitute a large superfamily of membrane proteins with key roles in cellular signaling. Upon activation by a ligand, GPCRs transduce signals from the extracellular to the intracellular environment. LÄS MER

  7. 15. Regulation of dioxin receptor activity by phosphorylation and protein-protein interaction

    Författare :Ingemar Pongratz; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The dioxin receptor together with its partner factor Arnt belongs to the basic helix-loop-helix/PAS family of transcription factors. The receptor is the mediator of the biological effects of a number of environmental pollutants such as dioxin and other related compounds. LÄS MER