Sökning: "structural biology"

Visar resultat 1 - 5 av 785 avhandlingar innehållade orden structural biology.

  1. 1. Evolutionary and Pharmacological Studies of NPY and QRFP Receptors

    Detta är en avhandling från Uppsala, Sweden : Acta Universitatis Upsaliensis

    Författare :Bo Xu; Uppsala universitet.; [2014]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Neuropeptide Y; genome duplication; Evolution; vertebrate; Pharmacology; Modelling; Kinetics; Bioinformatik; Bioinformatics; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik; Biologi med inriktning mot evolutionär funktionsgenomik; Biology with specialization in Evolutionary Functional Genomics; Farmaceutisk farmakologi; Pharmaceutical Pharmacology;

    Sammanfattning : The neuropeptide Y (NPY) system consists of 3-4 peptides and 4-7 receptors in vertebrates. It has powerful effects on appetite regulation and is involved in many other biological processes including blood pressure regulation, bone formation and anxiety. LÄS MER

  2. 2. Prediction of zinc-binding sites in proteins and efficient protein structure description and comparison

    Detta är en avhandling från Uppsala, Sweden : Acta Universitatis Upsaliensis

    Författare :Nanjiang Shu; Stockholms universitet.; [2008]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; zinc-binding; shape strings; protein structures; secondary structures; machine learning; NATURAL SCIENCES Biology Cell and molecular biology Molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi Molekylärbiologi; NATURAL SCIENCES Chemistry Biochemistry; NATURVETENSKAP Kemi Biokemi; NATURAL SCIENCES Biology Other biology Bioinformatics; NATURVETENSKAP Biologi Övrig biologi Bioinformatik; NATURAL SCIENCES Chemistry Biochemistry Structural biology; NATURVETENSKAP Kemi Biokemi Strukturbiologi; biokemi; Biochemistry; Structural Biology; strukturbiologi; Molecular Biology; molekylärbiologi;

    Sammanfattning : A large number of proteins require certain metals to stabilize their structures or to function properly. About one third of all proteins in the Protein Data Bank (PDB) contain metals and it is estimated that approximately the same proportion of all proteins are metalloproteins. LÄS MER

  3. 3. Combined structural methods to characterize an oligomeric small heat shock protein Hsp21

    Detta är en avhandling från Lund University, Faculty of Science, Department of Chemistry, Division of Biochemistry and Structural Biology

    Författare :Gudrun Rutsdottir; Lund University.; Lunds universitet.; [2017-05]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Small heat shock proteins; chaperones; crosslinking mass spectrometry; Stable isotope labeling; quantification; small angle X-ray scattering; cryo-electron microscopy; combined structural methods; plant stress;

    Sammanfattning : Small heat shock proteins (sHsps) are found in all organisms and evolved early in the history of life, prior to the divergence of the three domains of life (Archaea, Bacteria, and Eukarya). Their malfunction is connected to several different diseases in humans, such as Alzheimer’s and Parkinson’s disease. LÄS MER

  4. 4. The Design and Structure Prediction of Protein Oligomers

    Detta är en avhandling från Department of Biochemistry and Structural Biology, Lund University

    Författare :Robert Lizatovic; Lund University.; Lunds universitet.; [2015]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; virus capsids; coiled coils; molecular replacement; symmetry; Rosetta; protein design; structure prediction;

    Sammanfattning : The minimum free energy state of a protein (the native state) is encoded by its amino-acid sequence. Due to the many torsional degrees of freedom (DOF) available to a polypeptide chain, a vast number of conformations is possible. LÄS MER

  5. 5. Unveiling Mechanistic Details of Macromolecular Interactions: Structural Design and Molecular Modelling of DNA-Protein Systems in Their Active State

    Detta är en avhandling från Department of Biochemistry and Structural Biology, Lund University

    Författare :Anna Reymer; [2012]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; molecular modelling; intercalation; homologous recombination; DNA; ruthenium II polypyridyl compounds; human Rad51;

    Sammanfattning : Molecular structure is fundamental for understanding mechanisms of molecular interactions. This applies not least to understanding biological function: every biological cell, whether bacterial or human, is an immensely complex system of thousands of molecules that exist in constant motion and interaction with each other. LÄS MER