Sökning: "forebrain"

Visar resultat 11 - 15 av 105 avhandlingar innehållade ordet forebrain.

  1. 11. EMBRYONIC GLIA AND FOREBRAIN NEUROGENESIS; in vitro generation and differentiation of telencephalic neurons

    Författare :Charlotta Skogh; Neurobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; beta tubulin III; GFAP; RC2; Neurology; neuropsychology; neurofysiologi; DARPP-32; retinoic acid; serum; EGF; co-culture; cell culture; striatum; LGE; progenitor; precursor; radial glia; region specific; development; CNS; mouse; human; neurophysiology; Neurologi; neuropsykologi;

    Sammanfattning : The current thesis is aimed to increase our understanding of the generation and differentiation of telencephalic neurons, with emphasis on the role of glial cells in these processes. Using in vitro methods we have studied the role of glial cells in neurogenesis, inheritance of genetic regional specification, and influence on differentiation of neurons. LÄS MER

  3. 12. In vitro studies on human first trimester forebrain cells : differentiation and interactions with immunoregulating molecules

    Författare :Alyaa Mohammed Ali Mousa; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This thesis has focused on understanding, at the molecular level, growth regulation and differentiation of human first trimester forebrain cells, and the immune signals mediating these processes. Primary cultures were established from human forebrain tissue derived from elective first trimester abortions. LÄS MER

  4. 13. On the role of forebrain cholinergic innervation for phencyclidine-induced behaviors and gene expression patterns

    Författare :Sophia Savage; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The basalo-cortical cholinergic innervation reaches neural targets in cortex cerebri where it modulates the incoming sensory information, regulating arousal, attention, vigilance, memory and cognition. Progressive de generation of the cholinergic neurons in the basal forebrain is considered a hallmark of Alzheimer ’s disease related to cognitive impairment in this condition. LÄS MER

  5. 14. Characterization of evolutionary conserved subdomains in the embryonic zebrafish forebrain based on gene expression patterns

    Författare :Gilbert Lauter; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Intersecting transverse and longitudinal transcription factor expression domains divide the embryonic brain into a grid of histogenetic fields with distinct positional identities. The topology of histogenetic fields has been highly conserved during vertebrate evolution and can therefore be used to reveal homologous relations of brain areas between vertebrates. LÄS MER

  7. 15. Cholecystokinin, dopamine and glutamate in subcortical and peripheral control of food intake

    Författare :Min Qian; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :cholecystokinin; dopamine; glutamate; food intake;

    Sammanfattning : This thesis analyzes some of the mechanisms whereby cholecystokinin octapeptide (CCK-8) inhibits food intake in male rats. Depletion of monoamines using reserpine blocked the capacity for ingestive responses. These responses were restored in reserpinized rats by treatment with the non-competitive N-methyl-D-aspartate receptor antagonist MK-801. LÄS MER