Sökning: "drug disposition"

Visar resultat 26 - 30 av 42 avhandlingar innehållade orden drug disposition.

  1. 26. Applied Population Pharmacokinetic/ Pharmacodynamic Modeling of Antiretroviral and Antimalarial Drug Therapy

    Författare :Daniel Röshammar; Göteborgs universitet; []
    Nyckelord :HIV; malaria; pharmacokinetics; pharmacodynamics; pharmacometrics; NONMEM;

    Sammanfattning : HIV/AIDS and malaria are two major global infectious diseases. Although better drugs against these conditions are becoming more available, dosages may not always be optimal with respect to effectiveness, safety, cost or convenience of administration. LÄS MER

  3. 27. Characteristics of cytochrome P450-catalysed drug metabolism with focus on a black Tanzanian population

    Författare :Agneta Wennerholm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Drug metabolism; cytochrome P450; polymorphism; pharmacogenetics; genotyping; phenotyping; CYP2D6; CYP3A; debrisoquine; amodiaquine; alprazolam;

    Sammanfattning : The cytochrome P450 (CYP) enzymes display interindividual and interethnic variability that may alter the disposition of substances metabolised by these enzymes. Both genetic and environmental factors such as concomitant drug use and concurrent diseases influence the activities of these enzymes. LÄS MER

  4. 28. Pharmacogenetics and Antipsychotic Treatment in Schizophrenia with Special Focus on Adverse Drug Reactions

    Författare :Arzu Gunes; Marja-Liisa Dahl; Maria Gabriella Scordo; Kristina I. Melkersson; Jürgen Brockmöller; Uppsala universitet; []
    Nyckelord :Medicine; Pharmacogenetics; schizophrenia; antipsychotic treatment; adverse effects; clinical outcome; Medicin;

    Sammanfattning : Genetically determined differences in drug metabolism and disposition and drug targets play a pivotal role in the interindividual variability in the clinical outcome of antipsychotic treatment. The aim of this thesis was to study the impact of polymorphisms in genes involved in the pharmacokinetics and pharmacodynamics of antipsychotics, with special focus on their extrapyramidal and metabolic adverse effects. LÄS MER

  5. 29. Clinical studies on drug treatment of hospitalised patients : general infectious diseases and acute myocardial infarction

    Författare :Ksenia Zagorodnikova; Ksenia Goryachkina; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Treatment of hospitalised patients is generally governed by the pre-developed algorithms and common guidelines. These approaches are helpful in most, but not all cases. Treatment of hospitalised patients is limited to the time of hospital stay and is therefore directed to immediate help. LÄS MER

  7. 30. Experimental design of phenotyping probe drugs with emphasis on CYP1A2 : their use in studies on genetic and environmental regulation of drug metabolism

    Författare :Magnus Christensen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Drug metabolism; phenotype; CYP1A2; caffeine; melatonin; fluvoxamine; omeprazole; losartan; debrisoquine; quinine; genotype; single nucleotide polymorphism;

    Sammanfattning : Assessment of the cytochrome (CYP) P450 enzyme activity or phenotyping is a method to characterise the real activity of an enzyme by the use of a marker probe drug. The information of the phenotype is of clinical relevance because it reflects the combined effects of genetic, environmental e.g. LÄS MER