Sökning: "non-genomic"

Visar resultat 1 - 5 av 12 avhandlingar innehållade ordet non-genomic.

  1. 1. Neurosteroids Induce Allosteric Effects on the NMDA Receptor : Nanomolar Concentrations of Neurosteroids Exert Non-Genomic Effects on the NMDA Receptor Complex

    Författare :Tobias Johansson; Fred Nyberg; Pierre Le Grevès; Elisabeth Hansson; Uppsala universitet; []
    Nyckelord :Pharmaceutical pharmacology; Pharmacology; neurosteroids; NMDA receptor; NR2B subunit; ifenprodil; sigma receptor; anabolic androgenic steroids; allosteric modulation; non-genomic; Farmaceutisk farmakologi;

    Sammanfattning : The neurosteroids constitute a group of powerful hormones synthesized and acting in the central nervous system. They participate in a number of important central processes, such as memory and learning, mood and neuroprotection. LÄS MER

  3. 2. Genomic and non-genomic effects of a new sodium-sensing network in renal and lung epithelia

    Författare :Kristina Eneling; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Sodium and water homeostasis is crucial for cell function, survival and health of the individual. The kidney is responsible for sodium regulation in the body, balancing sodium secretion and reabsorption, and thereby also regulating the blood pressure, primarily via the Na+, K -ATPase. LÄS MER

  4. 3. The role of progesterone in the regulation of ciliary activity in the fallopian tube

    Författare :Magdalena Nutu; Göteborgs universitet; []
    Nyckelord :progesterone; progesterone receptor; non-genomic progesterone receptor; ciliated cells; fallopian tube; gamete transport; ciliary activity; ciliary beat frequency; reproduction; fertility;

    Sammanfattning : The overall aim of this thesis was to investigate the distribution and regulation of membrane progesterone receptors (mPRs) that may be involved in regulating ciliary activity in the fallopian tube. The fallopian tube serves to transport the egg and spermatozoa to achieve fertilization. LÄS MER

  5. 4. G protein-coupled estrogen receptor 1 (GPER) in the female reproductive tract: from physiology to cancer

    Författare :Zuzana Kolkova; Lund Obstetrik och gynekologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Estrogen effects are mediated either through genomic action involving the classical estrogen receptors, estrogen receptor alpha (ERα) and beta (ERß), which function as transcription factors in the nucleus, or through rapid non-genomic action via receptors associated with plasma membrane. Recently, a member of the G protein-coupled receptor family was ascribed estrogen receptor properties and proposed as a candidate for mediating non-genomic estrogen signaling. LÄS MER

  7. 5. Molecular mechanisms of alternative estrogen receptor signaling

    Författare :Linda Björnström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Estrogen is a key regulator of growth, differentiation and function in a broad range of target tissues, including the male and female reproductive tracts, mammary gland, bone, brain and the cardiovascular system. The biological effects of estrogen are mediated through estrogen receptor a (ERalpha) and estrogen receptor beta (ERbeta), which belong to a large superfamily of nuclear receptors that act as ligand-activated transcription factors. LÄS MER