Sökning: "drug disposition"

Visar resultat 21 - 25 av 42 avhandlingar innehållade orden drug disposition.

  1. 21. Bioanalytical development for application in therapeutic drug monitoring : focus on drugs used in psychiatry

    Författare :Daniel Öhman; Olof Beck; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Introduction: Since the 1950s and onwards, many new psychoactive drugs have been successfully introduced in clinical practice. A common feature of these drugs is a profound metabolism before clearance from the body. LÄS MER

  3. 22. Consequences of CYP2D6 polymorphism for the disposition and dynamics of tolterodine : a novel drug in the treatment of urinary bladder overactivity

    Författare :Niclas Brynne; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :active metabolite; CYP2D6; CYP3A4; disposition; drug interaction; fluoxetine; ketoconazole; metabolic ratio; pharmacokinetics; tolterodine;

    Sammanfattning : The pharmacokinetics and pharmacological effects of tolterodine were studied in man following administration of increasing oral and intravenous single-doses. The influence of metabolic phenotype in extensive and poor metabolizers of debrisoquine was determined. LÄS MER

  4. 23. Överdosens antropologi : En kontextuell studie

    Författare :Eva-Malin Antoniusson; Socialhögskolan; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; anthropology; overdose; drug users; retrospective ritualization; national insurance; Social problems and welfare; Sociala problem; social välfärd; socialförsäkring;

    Sammanfattning : The central theme of this thesis is the nature of heavy drug overdose and its social consequences. The aim of the study is to provide a nuanced ethnographic interpretation on the phenomenon concerning drug overdose, especially among drug users using injections as the principle means of administering the drugs. LÄS MER

  5. 24. Involvement of Membrane Transport Proteins in Intestinal Absorption and Hepatic Disposition of Drugs Using Fexofenadine as a Model Drug

    Författare :Niclas Petri; Hans Lennernäs; Geoffrey Tucker; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biopharmacy; Fexofenadine; OATP; P-glycoprotein; Organic Anion Transporters; ATP-Binding Cassette Transporters; membrane transport proteins; Bioavailability; Biopharmaceutics; Biofarmaci; Biopharmacy; Biofarmaci;

    Sammanfattning : The aims of this thesis were to study the in vivo relevance of membrane transporters for intestinal absorption and the hepatic disposition of drugs in humans and preclinical models. Fexofenadine is a substrate for ABCB1 (P-glycoprotein) and members of the organic anion transporting polypeptide (OATP/SLCO) family. LÄS MER

  7. 25. On the hypersensitivity syndrome induced by the selective serotonin reuptake inhibiting antidepressant Zimeldine : A clinical and experimental study

    Författare :Bengt-O Bengtsson; Linköpings universitet; []
    Nyckelord :Zimeldine; Norzimeldine; Hypersensitivity syndrome; Serotonin reuptake inhibition; Genetic disposition; Lymphocyte transformation test; Experimental allergic neuritis; Immunopharmacology; MEDICINE; MEDICIN;

    Sammanfattning : Zimeldine, the first selective neuronal serotonin (5-H1) reuptake inhibitor to be registered as an antidepressant was withdrawn from common use due to an acute flu-like adverse syndrome comprising fever, myalgia and/or arthralgia and signs of disturbed liver function. A few of these patients also developed a peripheral neuropathy, in the most serious form a Guillain-Barré syndrome (GBS). LÄS MER