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Visar resultat 11 - 15 av 133 avhandlingar som matchar ovanstående sökkriterier.

1. 11. Effects of Microparticulate Drug Delivery Systems : Tissue Responses and Transcellular Transport

   Författare :Eva Ragnarsson; Per Artursson; Lucia Lazorova; David Brayden; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; microparticles; vaccine; pDNA vaccine; cationic polymer; gene expression analysis DNA array ; Caco-2; follicle-associated epithelium FAE ; M cell; transcytosis; Yersinia pseudotuberculosis; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

   Sammanfattning : Over the past decade, the development of macromolecular drugs based on peptides, proteins and nucleic acids has increased the interest in microparticulate drug delivery, i.e., the delivery of drug systems in the nanometer and micrometer ranges. LÄS MER

3. 12. Environment-Sensitive Multifunctional Drug Delivery Systems

   Författare :Jian Qin; Mamoun Muhammed; Marcus Textor; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Materials chemistry; Materialkemi;

   Sammanfattning : Drug delivery systems (DDS) with multiple functionalities such as environment-sensitive drug release mechanisms and visualization agents have motivated the biomedical community as well as materials chemists for more than a decade. This dissertation is concerned with the development of nanoparticles for multifunctional DDS  to tackle several crucial challenges in these complex systems, including polymeric nanospheres which respond to temperature change, superparamagnetic iron oxide nanoparticles/polymeric composite for magnetic resonance imaging contrast agents and drug carriers, immunoresponse of nanomaterials and injectable magnetic field sensitive ferrogels. LÄS MER

4. 13. Mesoporous Implants for Localized Controlled Drug Delivery

   Författare :Johan Karlsson; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; release kinetics; mesoporous titania; biomineralization; drug delivery; Biomedical implants; osseointegration; osteoporosis drugs; nanotopography; stem cells homing;

   Sammanfattning : The use of bone-anchored implants is today a routine treatment for patients with normal regenerative capacity. However, there is an ongoing development within implant research to improve the osseointegration of implants. LÄS MER

5. 14. Characterisation of an in vitro dissolution method for assessment of novel pulmonary drug delivery systems : With a focus on controlled release systems

   Författare :Irès van der Zwaan; Göran Frenning; Per Hansson; Rebecca Fransson; Alessandra Rossi; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pulmonary drug delivery; in vitro dissolution; mechanistic model; controlled release; physiologically based biopharmaceutics modelling;

   Sammanfattning : Pulmonary drug delivery has been used for decades to treat local diseases like asthma. When using the pulmonary route to deliver drugs, several important lung features are being used, such as a large surface area available for absorption, high organ vascularization, and a thin blood-alveolar barrier. LÄS MER

7. 15. Advancing portable, aqueous drug delivery to the human lung

   Författare :Torben Last; Göran Stemme; Niclas Roxhed; Claus-Michael Lehr; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Portable Inhaler; Biopharmaceuticals; Soft-mist inhaler; Transport vesicles; Microfluidic packaging; High-pressure microfluidics; aerosolization; cleanroom-free fabrication; drug delivery; micro-electromechanical systems MEMS ; Applied Medical Technology; Tillämpad medicinsk teknik;

   Sammanfattning : Lung disease profoundly impacts human health: many lung diseases are currently without cure and require continued treatment. Due to their ease of use and integration into the daily routine, portable inhalers are the preferred treatment option for patients. LÄS MER