Sökning: "pkd1"

Hittade 2 avhandlingar innehållade ordet pkd1.

  1. 1. Development of benzoquinoquinoxaline derivatives as triplex-specific probes : Recognition of DNA structures at repeats sequences

    Detta är en avhandling från Stockholm : Department of Molecular Biology and Functional Genomics, Stockholm University

    Författare :Helen Bergquist; Rula Zain; Keith Fox; [2011]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Triplex; H-DNA; BQQ; BQQ-OP; BQQ-Bodipy; triplet repeat; DNA; non-B-DNA; pkd1; frataxin; Friedreich s ataxia; NATURAL SCIENCES Biology Cell and molecular biology Molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi Molekylärbiologi; Molecular Biology; molekylärbiologi;

    Sammanfattning : Repeat sequences are associated with several human diseases, such as Friedreich’s ataxia, polycystic kidney disease and cancer. These sequences can form non-B-DNA structures, including triplex (H-DNA) DNA, and are associated with genomic instability and altered gene expression. LÄS MER

  2. 2. Structural and functional studies of the secreted metalloprotease PrtV from Vibrio cholerae

    Detta är en avhandling från Umeå : Umeå universitet

    Författare :Aaron Edwin; Elisabeth Sauer-Eriksson; Helena Berglund; [2014]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cholera; Vibrio cholerae; virulence factors; PrtV; X-ray crystallography; NMR;

    Sammanfattning : Cholera, an acute diarrheal diseases caused by the intestinal infection of the pathogenic bacterium Vibrio cholerae, continues to be a global killer in the world today. PrtV, a secreted zinc metalloprotease, is a potent cytotoxic virulence factor of V. cholerae. LÄS MER