Sökning: "dipeptidyl peptidase-4"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden dipeptidyl peptidase-4.

1. 1. Impaired Glucose Tolerance in Childhood Obesity : Contribution of Glucagon, GLP-1 and Inflammation

   Författare :Hannes Manell; Peter Bergsten; Anders Forslund; Jens Juul Holst; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Childhood obesity; impaired glucose tolerance; type 2 diabetes; glucagon; glucagon-like peptide-1; dipeptidyl peptidase-4; inflammation; free fatty acids; insulin; visceral adiposity; Medicinsk vetenskap; Medical Science;

   Sammanfattning : In the wake of increased obesity prevalence, impaired glucose tolerance (IGT) and type 2 diabetes (T2D) in childhood and adolescence is increasingly common. Given the negative impacts these conditions have on health over time, understanding the pathophysiology in those affected early in life is important. LÄS MER

3. 2. Novel insights into the regulation of insulin secretion by GLP-1, GIP and glucagon

   Författare :Linda Ahlkvist; Lund Medicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vagus nerve; GPR119; Insulin resistance; Glucagon; GIP; GLP-1; Insulin;

   Sammanfattning : There are many contributing factors to the development of type 2 diabetes, however, failure of beta-cells to sufficiently secrete insulin is the key component. The underlying mechanism of beta-cell failure is not fully established. In this thesis, we examined the role of high glucagon levels, i.e. LÄS MER

4. 3. Human adipose tissue morphology and function : relation to insulin sensitivity and glucose tolerance with focus on pregnancy and women with previous gestational diabetes mellitus

   Författare :Henrik Svensson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adipose tissue; Adipocyte; Adipokines; Insulin resistance; Pregnancy; Gestational diabetes mellitus; Type 2 diabetes;

   Sammanfattning : Obesity is a global health problem and affects women of reproductive age. During pregnancy, obesity increases the risk for gestational diabetes mellitus (GDM), in turn predisposing for type 2 diabetes (T2D). LÄS MER

5. 4. Role and therapeutic potential of non-coding RNAs in vascular remodeling and atherosclerotic plaque formation

   Författare :Suzanne M Eken; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Atherosclerosis and its clinical sequelae remain a world leading cause of disease and death, despite recent advances in primary and secondary prevention. The silently progressive character of the disease, in combination with the influence of individual patient characteristics, makes acute events difficult to predict and prevent. LÄS MER

7. 5. Glucagon Counter-Regulation to Hypoglycemia During Incretin-Based Therapy

   Författare :Johan Farngren; Lund Medicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Incretin; DPP-4; GLP-1; Glucagon; Hypoglycemia; Diabetes;

   Sammanfattning : Incretin-based therapy is associated with low risk of hypoglycemia in type 2 diabetes mellitus (T2DM) possibly due to its glucose-dependency in stimulating insulin secretion and a sustained glucagon response during hypoglycemia. This is of special relevance when it is combined with insulin or given to elderly patients since both insulin therapy and high age are associated with impaired glucagon counter-regulation. LÄS MER