Sökning: "DPP-4"
Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet DPP-4.
1. On Meal Effects and DPP-4 Inhibition Islet- and Incretin Hormones in Health and Type 2 Diabetes
Sammanfattning : .... LÄS MER
2. Glucagon Counter-Regulation to Hypoglycemia During Incretin-Based Therapy
Sammanfattning : Incretin-based therapy is associated with low risk of hypoglycemia in type 2 diabetes mellitus (T2DM) possibly due to its glucose-dependency in stimulating insulin secretion and a sustained glucagon response during hypoglycemia. This is of special relevance when it is combined with insulin or given to elderly patients since both insulin therapy and high age are associated with impaired glucagon counter-regulation. LÄS MER
3. Novel insights into the regulation of insulin secretion by GLP-1, GIP and glucagon
Sammanfattning : There are many contributing factors to the development of type 2 diabetes, however, failure of beta-cells to sufficiently secrete insulin is the key component. The underlying mechanism of beta-cell failure is not fully established. In this thesis, we examined the role of high glucagon levels, i.e. LÄS MER
4. Impaired Glucose Tolerance in Childhood Obesity : Contribution of Glucagon, GLP-1 and Inflammation
Sammanfattning : In the wake of increased obesity prevalence, impaired glucose tolerance (IGT) and type 2 diabetes (T2D) in childhood and adolescence is increasingly common. Given the negative impacts these conditions have on health over time, understanding the pathophysiology in those affected early in life is important. LÄS MER
5. Towards a Health Economic Simulation Model of Type 2 Diabetes in Sweden
Sammanfattning : The aim of this thesis was to provide part of the data required in updating/developing computer simulation models (CSMs) for type 2 diabetes mellitus (T2DM) using data obtained from routine clinical practice in Sweden. In paper I, evolution of five biomarkers (i.e. LÄS MER