Sökning: "Incretin"

Visar resultat 1 - 5 av 30 avhandlingar innehållade ordet Incretin.

  1. 1. Incretin Hormone Secretion - Studies in Human Subjects

    Författare :Ola Lindgren; Lund Medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; insulin; obesity; GLP-1; GIP; incretin;

    Sammanfattning : Several different hormones are released from the intestine following a meal. In this thesis we have focused on the so called incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). LÄS MER

  3. 2. On the Impact of Bariatric Surgery on Glucose Homeostasis

    Författare :Niclas Abrahamsson; Britt Eden Engström; Jan Eriksson; Magnus Sundbom; Neil Gerard Docherty; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hypoglycaemia; Gastric Bypass surgery; Biliopancreatic diversion with duodenal switch DS ; NT-ProBNP; Continuous glucose measuring system CGMS ; GLP-1-analog; glucose variability; MAGE; CONGA; counter regulation; incretin; Heart Rate Variability; Endocrinology and Diabetology; Endokrinologi och Diabetologi;

    Sammanfattning : Obesity has grown to epidemic proportions, and in lack of efficient life-style and medical treatments, the bariatric surgeries are performed in rising numbers. The most common surgery is the Gastric Bypass (GBP) surgery, with the Biliopancreatic diversion with duodenal switch (DS) as an option for the most extreme cases with a BMI>50 kg/m2. LÄS MER

  4. 3. Physiology and Pathophysiology of Hormone Secretion from lslets of Langerhans

    Författare :Samuel Acreman; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Islet; diabetes; glucagon; insulin; somatostatin; incretin; pancreas; hypoglycaemia; tetraspanin; GLP-1; endoplasmic reticulum;

    Sammanfattning : Diabetes is a metabolic disorder stemming from the improper regulation of blood glucose levels by hormones secreted by pancreatic islets of Langerhans. Paper I describes the mechanism by which glucose can regulate glucagon secretion, independent of membrane potential, from pancreatic α-cells, via modulation of endoplasmic reticulum Ca2+ handling. LÄS MER

  5. 4. On Meal Effects and DPP-4 Inhibition Islet- and Incretin Hormones in Health and Type 2 Diabetes

    Författare :Wathik Alsalim; Lund Medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 diabetes; Healthy subjects; Meal composition; Incretin hormones; DPP-4 inhibition;

    Sammanfattning : .... LÄS MER

  7. 5. Glucagon Counter-Regulation to Hypoglycemia During Incretin-Based Therapy

    Författare :Johan Farngren; Lund Medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Incretin; DPP-4; GLP-1; Glucagon; Hypoglycemia; Diabetes;

    Sammanfattning : Incretin-based therapy is associated with low risk of hypoglycemia in type 2 diabetes mellitus (T2DM) possibly due to its glucose-dependency in stimulating insulin secretion and a sustained glucagon response during hypoglycemia. This is of special relevance when it is combined with insulin or given to elderly patients since both insulin therapy and high age are associated with impaired glucagon counter-regulation. LÄS MER