Sökning: "four-helix bundle"
Visar resultat 1 - 5 av 12 avhandlingar innehållade orden four-helix bundle.
1. Polypeptide-Based Nanoscale Materials
Sammanfattning : Self-assembly has emerged as a promising technique for fabrication of novel hybrid materials and nanostructures. The work presented in this thesis has been focused on developing nanoscale materials based on synthetic de novo designed polypeptides. LÄS MER
2. Targeting Biological Systems by Organic Synthesis Methods - Cancer Cells and Proteins
Sammanfattning : This thesis describes the design and synthesis of molecules with potential roles in biomedicine, with an emphasis on molecular recognition in complex biological environments. The first chapter describes the synthesis and evaluation of compounds for use in nuclide therapy. LÄS MER
3. Structural Transitions in Helical Peptides : The Influence of Water – Implications for Molecular Recognition and Protein Folding
Sammanfattning : Fluctuations in protein structure are vital to function. This contrasts the dominating structure-function paradigm, which connects the well-defined three-dimensional protein structure to its function. However, catalysis is observed in disordered enzymes, which lack a defined structure. LÄS MER
4. Cooperative Reactive Sites in Designed Helix-Loop-Helix Polypeptide Catalysts
Sammanfattning : Designed polypeptides, which fold into helix-loop-helix motifs and dimerise to four-helix bundles have been used as scaffolds for the introduction of catalytic activity for the hydrolysis of p-nitrophenyl esters. The reactive sites were based on the reactivity of histidine, and two His residues separated by four residues in the sequence was shown to be the minimal reactive site for the efficient hydrolysis of nitrophenyl esters. LÄS MER
5. Protein-protein interactions in model systems : design, control of catalytic activity and biosensor applications
Sammanfattning : This thesis describes the design of polypeptides, unordered in the monomeric state but capable of folding into helix-loop-helix motifs and dimerise to form four-helix bundles. The goal of the design was to encode them with the capacity to form dimers highly selectively and the ability to carry out molecular functions in the folded state but not in the unordered state, and thus to establish a molecular link between recognition and function. LÄS MER
