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Visar resultat 6 - 10 av 39 avhandlingar som matchar ovanstående sökkriterier.

  1. 6. Development of novel bioanalytical assays with single-molecule readout for biomarker detection and drug candidate characterization

    Författare :Olov Wahlsten; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; QCM-D; biomarker detection; TIRF microscopy.; Bioanalytical assay; spectrofluorometry; fluorescence; single-molecule readout; drug discovery; liposomes;

    Sammanfattning : Bioanalytical assays with single-molecule readout for studying molecular interactions have in the past decades received increasing attention. The high sensitivity often offered by this readout scheme has for example enabled ultra-sensitive analyte detection, having important implications for monitoring early disease progression and the effects of drug treatment. LÄS MER

  3. 7. Lysosomal Involvement in the Pathogenesis of Alzheimer's Disease

    Författare :Lin Zheng; Jan Marcusson; Alexei Terman; Martin Hallbeck; Lars Nilsson; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Alzheimer’s disease (AD), the major cause of senile dementia, is associated with progressive formation of neurofibrillary tangles and extraneuronal plaques composed of amyloid beta peptide (Aβ). Aβ has been also found within Alzheimer neurons in association with the lysosomal system, an acidic vacuolar compartment possessing numerous hydrolytic enzymes. LÄS MER

  4. 8. Studies on the plasticity of glutamate receptors and its role for neuronal calcium homeostasis

    Författare :Linda Westin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Calcium is the most important and versatile signaling molecule in the brain. Neurons are equipped with a variety of tools to utilize this simple ion in diverse ways. From controlling the millisecond fast neurotransmitter release, to reshaping neuronal structure and function. LÄS MER

  5. 9. Antibody-based subcellular localization of the human proteome

    Författare :Marie Skogs; Emma Lundberg; Hans Blom; Cecilia Williams; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Human proteome; Subcellular localization; Organelles; Immunofluorescence; Fixation; Permeabilization; Antibody validation; Bioteknologi; Biotechnology;

    Sammanfattning : This thesis describes the use of antibodies and immunofluorescence for subcellular localization of proteins. The key objective is the creation of an open-source atlas with information on the subcellular location of every human protein. LÄS MER

  7. 10. Basement membrane components and their receptors in organogenesis

    Författare :Katriina Salmivirta; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Basement membrane; laminin; collagen type IV; nidogen; integrin; morphogenesis; organogenesis; tooth; salivary gland; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; fysiologi; Physiology;

    Sammanfattning : During embryogenesis organs are formed from epithelial and mesenchymal tissues. Organogenesis is dependent on interactions between epithelium and mesenchyme. Specialized extracellular matrices, basement membranes, located between the two tissue types play a crucial role in mediating the interactions. LÄS MER