Sökning: "colocalization"

Visar resultat 1 - 5 av 34 avhandlingar innehållade ordet colocalization.

  1. 1. Spectral Image Processing with Applications in Biotechnology and Pathology

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Milan Gavrilovic; Uppsala universitet.; Uppsala universitet.; [2011]
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; color theory; light microscopy; spectral imaging; image analysis; digital image processing; mathematical modeling; estimation; noise models; spectral decomposition; color decomposition; colocalization; cross-talk; autofluorescence; tissue separation; prostate cancer; biomedical applications; molecular biotechnology; histopathology; Computerized Image Processing; Datoriserad bildbehandling;

    Sammanfattning : Color theory was first formalized in the seventeenth century by Isaac Newton just a couple of decades after the first microscope was built. But it was not until the twentieth century that technological advances led to the integration of color theory, optical spectroscopy and light microscopy through spectral image processing. LÄS MER

  2. 2. Plasma membrane order; the role of cholesterol and links to actin filaments  

    Detta är en avhandling från Stockholm : The Wenner-Gren Institute, Stockholm University

    Författare :Jelena Dinic; Stockholms universitet.; [2011]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell Biology; cellbiologi; Membrane Organization; Lipid rafts; Actin; Laurdan; di-4-ANEPPDHQ; Cholesterol; T cell signaling; Colocalization; Generalized Polarization;

    Sammanfattning : The connection between T cell activation, plasma membrane order and actin filament dynamics was the main focus of this study. Laurdan and di-4-ANEPPDHQ, membrane order sensing probes, were shown to report only on lipid packing rather than being influenced by the presence of membrane-inserted peptides justifying their use in membrane order studies. LÄS MER

  3. 3. Assay development for studies of G protein-coupled receptors at the single-molecule level

    Detta är en avhandling från Stockholm : The Wenner-Gren Institute, Stockholm University

    Författare :Olov Wahlsten; [2014]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TIRF microscopy; colocalization; drug discovery; QCM-D; GPCR; pharmacodynamics; kinetics; equilibrium fluctuation analysis;

    Sammanfattning : G protein-coupled receptors (GPCRs), also known as seven transmembrane (7TM) receptors,is the largest family of cell surface receptors. These receptors play a key role in transmittinga wide variety of signals across the cell membrane and are involved in physiologicalprocesses such as sensory transduction, cell-cell communication, neuronal transmission,and hormonal signaling. LÄS MER

  4. 4. Oxygen-dependent regulation of transcription by the hypoxia-inducible factor-1

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Cell and Molecular Biology

    Författare :Jorge Lira Ruas; Karolinska Institutet.; Karolinska Institutet.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hypoxia; HIF-1; protein degradation; transcription; coactivators; CBP; subcellular localization; C1-tetrahydrofolate synthase;

    Sammanfattning : Under limited oxygen availability (hypoxia) cells undergo rapid reprogramming in order to survive in the new environment until normoxic conditions are re-established. The observation that hypoxia can induce the expression of genes involved in erythropoiesis, angiogenesis and glucose metabolism among others, led to the identification of the hypoxia-inducible factor-1 (HIF-1) as a master regulator of the hypoxia-response pathway. LÄS MER

  5. 5. The N-methyl-D-aspartate receptor subunit NR3A: : Cloning, expression and interacting proteins

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Neurobiology, Care Sciences and Society

    Författare :Maria Eriksson; Karolinska Institutet.; Karolinska Institutet.; [2008]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : This thesis focuses on the subunit NR3A, which together with subunits NR1, NR2A-NR2D and NR3B builds the excitatory glutamate receptor N-methyl-D-aspartate (NMDA). The receptor is most likely a tetramer, containing at least one NR1, probably two NR2 and sometimes one NR3 subunit. LÄS MER