Sökning: "collagen binding protein."

Visar resultat 21 - 25 av 72 avhandlingar innehållade orden collagen binding protein..

1. 21. Proteoglycan Lectin Domain Interactions in Extracellular Matrix Assembly

   Författare :Anders Olin; Infektionsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicinska vetenskaper allmänt ; General biomedical sciences; crystal structure; network formation; collagen IX; N-glycans; PRELP; cross-linking; fibulin-2; lectin; G3; ECM; proteoglycan;

   Sammanfattning : This thesis focuses on the C-terminal G3 region of the large aggregating proteoglycans that are found in complex with hyaluronan in the extracellular matrix. The G3 region contains a C-type lectin domain that binds different extracellular matrix proteins playing an integral role in tissue organization during development and remodeling. LÄS MER

3. 22. Identification and functional analysis of anti-citrullinated protein antibodies in rheumatoid arthritis

   Författare :Yibo He; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Rheumatoid arthritis (RA) is a complex autoimmune disease and typically manifested by joint inflammation and bone erosion with approximately 0.5% of the global population affected. To date, it is believed that genetic predisposition (e.g. LÄS MER

4. 23. Modified Glycopeptides Targeting Rheumatoid Arthritis : Exploring molecular interactions in class II MHC/glycopeptide/T-cell receptor complexes

   Författare :Ida E. Andersson; Jan Kihlberg; Anna Linusson Jonsson; Craig Crews; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Major histocompatibility complex; class II MHC; T-cell receptor; rheumatoid arthritis; collagen-induced arthritis; glycopeptide; amide bond isostere; comparative modeling; rational design; molecular docking; molecular dynamics simulation; statistical molecular design; Bioorganic chemistry; Bioorganisk kemi; organisk kemi; Organic Chemistry; Biorganic Chemistry; bioorganisk kemi; datorlingvistik; computational linguistics;

   Sammanfattning : Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that leads to degradation of cartilage and bone mainly in peripheral joints. In collagen-induced arthritis (CIA), a mouse model for RA, activation of autoimmune CD4+ T cells depends on a molecular recognition system where T-cell receptors (TCRs) recognize a complex between the class II MHC Aq protein and CII259-273, a glycopeptide epitope from type II collagen (CII). LÄS MER

5. 24. Basement membrane components and their receptors in organogenesis

   Författare :Katriina Salmivirta; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Basement membrane; laminin; collagen type IV; nidogen; integrin; morphogenesis; organogenesis; tooth; salivary gland; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; fysiologi; Physiology;

   Sammanfattning : During embryogenesis organs are formed from epithelial and mesenchymal tissues. Organogenesis is dependent on interactions between epithelium and mesenchyme. Specialized extracellular matrices, basement membranes, located between the two tissue types play a crucial role in mediating the interactions. LÄS MER

7. 25. Analysis of antibodies to cartilage oligomeric matrix protein in rheumatoid arthritis and in mouse models

   Författare :Weiwei Cai; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Rheumatoid arthritis (RA), a common autoimmune disease, affects 0.5-1% of the world’s population. It is not only an important health problem but also a socioeconomic problem considering that it can lead to joint destruction and disability. It is well known that the disease can actually start many years ahead of the clinical onset. LÄS MER