Sökning: "clonal evolution"

Visar resultat 16 - 20 av 40 avhandlingar innehållade orden clonal evolution.

  1. 16. Inter and intra-tumor models of somatic evolution in cancer

    Författare :Mohammadreza Mohaghegh Neyshabouri; Jens Lagergren; Ben Raphael; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cancer progression models; MCMC; Tillämpad matematik och beräkningsmatematik; Applied and Computational Mathematics;

    Sammanfattning : Cancer is a disease caused by the accumulation of somatic mutations in an evolutionary process. Mutations in so-called cancer driver genes provide the harboring cells with particular selective advantages and result in cancer progression. LÄS MER

  3. 17. Hopeful monsters: The role of hybrids in adaptation : The impact of hybridisation and genetic diversity on adaptation to stressful and novel environments

    Författare :Ciaran Gilchrist; Rike Stelkens; Christopher Wheat; Linda Laikre; Mathilde Cordellier; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Experimental evolution; Saccharomyces cerevisiae; population genetics; hybridisation; adaptation; aneuploidy; comparative genomics; evolve-and-resequence; de novo mutations; evolutionary parallelism; populationsgenetik; Population Genetics;

    Sammanfattning : Adaptation to novel environments can only occur if natural selection has the raw material to act upon. But small, endangered populations are often genetically depleted, and the acquisition of beneficial de novo mutations often takes too long when population face quick and extreme environmental change. LÄS MER

  4. 18. Molecular Interrogation and Functional Studies of Acute Leukemia

    Författare :Axel Hyrenius Wittsten; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute leukemia; KMT2A; Cooperating Lesions; Clonal Relationship; Genomic Profiling; Fusion Genes;

    Sammanfattning : Hematological malignancies are defined by their underlying genetic alterations, many of which are used to diagnose patients to classify them to different risk groups that dictate the therapy given. Recent advances in high-throughput sequencing have highlighted the presence of co-occurring genetic lesions and that they may form distinct genetic clones that evolve throughout disease progression. LÄS MER

  5. 19. Detection of immunoglobulin heavy chain gene rearrangement with PCR for MRD analysis in lymphoproliferative disorders

    Författare :Ulf Thunberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Minimal residual disease; Immunoglobulin gene rearrangement; PCR; Leukemia; Lymphoma; Myeloma; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : Immunoglobulin heavy chain (IGH) gene rearrangement occurs during early B-lymphocyte differentiation, assembling the different IGH gene segments to a functional gene, which can serve as a marker for study of lineage association and detection of Minimal Residual Disease (MRD) in clonal diseases deriving from B-lymphocytes or their early differentiation stages. Use of a molecular marker for the leukemic cells could help improve treatment by monitoring therapeutic efficacy, predicting relapse, and identifying very small amounts of tumour cells contaminating autografts after purging or enrichment of stem cells. LÄS MER

  7. 20. Studies of congenital genetic aberrations behind childhood leukemia

    Författare :Benedicte Bang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Acute lymphoblastic leukemia (ALL) is the most common cancer in childhood, and most frequently (85%) of B-cell precursor type (BCP-ALL). Acquired chromosomal rearrangements or aneuploidies are the recurrent, often prenatal, initiators of BCP-ALL. LÄS MER