Sökning: "cell fate specification"

Visar resultat 16 - 20 av 48 avhandlingar innehållade orden cell fate specification.

  1. 16. Genetic Alterations in Lymphoma : with Focus on the Ikaros, NOTCH1 and BCL11B Genes

    Författare :Anneli Karlsson; Peter Söderkvist; Shi-Mei Zhuang; Jan-Ingvar Jönsson; Dan Grandér; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell proliferation; Lymphoma; Znfn1a1; Notch1; Bcl11b; chromosomal regions; Ikaros; B-cell lymphomas; Oncology; Onkologi;

    Sammanfattning : Cell proliferation is a process that is strictly regulated by a large number of proteins. An alteration in one of the encoding genes inserts an error into the regulative protein, which may result in uncontrolled cell growth and eventually tumor formation. LÄS MER

  3. 17. Regional control of cell fate determination and neurogenesis in the developing CNS

    Författare :Ulrika Marklund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The development of a functional central nervous system relies on the generation of distinct neuronal subtypes in a spatially and temporally defined order. The spatial organisation is achieved at early developmental time points when neural progenitor cells encounter fields of secreted morphogenic signalling molecules along the anterioposterior and dorsoventral axes of the embryo. LÄS MER

  4. 18. Generation of cells for cell-replacement therapy: Specification of neural precursors in vivo and in neural stem cell cultures

    Författare :Josephine Hebsgaard; Neurobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurospheres; Dopaminergic neurons; Parkinson s disease; Neurogenin2;

    Sammanfattning : Cell replacement therapy of neurodegenerative disorders aims to substitute the degenerating cells with new functional neurons. Clinical trails with patients suffering from Parkinson’s or Huntington’s disease have generated proof-of-principle results that neural precursors taken from the developing human brain can survive upon grafting to the diseased brain and provide long-lasting symptomatic relief. LÄS MER

  5. 19. ELUCIDATING REGULATORY NETWORKS PROMOTING B-CELL DEVELOPMENT

    Författare :Eva Welinder; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : B-cells are an essential part of our adaptive immune system. A network of transcription factors together with external signals facilitate the gradual developmental progression from progenitor cells towards the B-cell fate. Several key factors participating in this network have been identified. LÄS MER

  7. 20. Characterization of human dopaminergic neurons in the developing mesencephalon and upon differentiation of stem cells- for replacement therapy in Parkinson´s disease

    Författare :Jenny Nelander Wahlestedt; Utvecklings- och regenerativ neurobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson´s disease; stem cells; ventral mesencephalon; dopaminergic neurons; cell replacement therapy; human fetal tissue; radial glia; microRNA; BAC recombineering; reporter cell lines;

    Sammanfattning : Cell-replacement therapy is a promising approach for treating patients with Parkinson ́s disease (PD). For this purpose, there is a need for developing a protocol that can generate high numbers of human transplantable mesencephalic dopaminer- gic (mesDA) neurons. LÄS MER