Sökning: "cell fate specification"

Visar resultat 11 - 15 av 48 avhandlingar innehållade orden cell fate specification.

  1. 11. Revisiting cell specification and differentiation in the Drosophila airways, an insect organ homologous to our lung and blood vessels

    Författare :Ryo Matsuda; Christos Samakovlis; Payre Francois; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cell differentiation; airways; Drosophila; cell signaling; transcription factors; utvecklingsbiologi; Developmental Biology;

    Sammanfattning : Oxygen is essential for life. Aquatic ancestral animal species are thought to have independently terrestrialized and invented distinct strategies for efficient oxygen supply. The respiratory system of vertebrates like us is composed of lungs connected to the vasculature while insects have a single system delivering air directly to internal tissues. LÄS MER

  3. 12. Genetic mechanisms controlling cell specification and cell numbers in the Drosophila CNS

    Författare :Carina Ulvklo; Stefan Thor; Jan-Ingvar Jönsson; Mattias Alenius; Ruth Palmer; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : A central theme in developmental neurobiology pertains to how the  diversity of different cell types is generated. In addition, it is equally important to understand how the specific numbers of each cell type is regulated. LÄS MER

  4. 13. Mechanisms of cell diversification

    Författare :Christopher Winston Uhde; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cell identity and function is determined by the intrinsic wiring of the gene regulatory network that endows progenitors with the competence to respond appropriately to extrinsic cues in a spatiotemporally-dependent manner. One such class of cues, morphogens, instruct cells in their identity by virtue of a concentration gradient, but how this is interpreted at gene regulatory levels to result in sharp and robust boundaries of gene expression is poorly understood. LÄS MER

  5. 14. Molecular mechanisms in lymphoid restriction : securing the B lineage fate

    Författare :Josefine Åhsberg; Mikael Sigvardsson; Jan-Ingvar Jönsson; Charles G. Mullighan; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : With the work in this thesis I have aimed to deepen the understanding of the mechanisms behind the development of different blood cell lineages with a specific focus on B cell development.To understand the interplay between extracellular signaling and transcription factor networks in early lymphoid development we investigated the functional collaborations of FLT3 and IL7R. LÄS MER

  7. 15. Spatial and temporal mechanisms of cell fate determination in the developing CNS

    Författare :José Dias; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The generation of neural cell diversity in the developing central nervous system relies on mechanisms that provide spatial and temporal information to neural progenitor cells. The deployment of morphogen gradients is an important strategy to impart spatial information to the field of responding cells. LÄS MER