Sökning: "Ulrika Marklund"
Hittade 4 avhandlingar innehållade orden Ulrika Marklund.
1. Regional control of cell fate determination and neurogenesis in the developing CNS
Sammanfattning : The development of a functional central nervous system relies on the generation of distinct neuronal subtypes in a spatially and temporally defined order. The spatial organisation is achieved at early developmental time points when neural progenitor cells encounter fields of secreted morphogenic signalling molecules along the anterioposterior and dorsoventral axes of the embryo. LÄS MER
2. Turn-taking and early phonology : Contingency in parent-child interaction and assessment of early speech production
Sammanfattning : This thesis focuses on contingency in parent-child interaction, investigating it in the light of the linguistic capacity of the child and the status of the caregiver. Further, the thesis covers the development of two tools to assess the developmental maturity level of expressive phonology. LÄS MER
3. Using patient-derived cell models to investigate the role of misfolded SOD1 in ALS
Sammanfattning : Protein misfolding and aggregation underlie several neurodegenerative proteinopathies including amyotrophic lateral sclerosis (ALS). Superoxide dismutase 1 (SOD1) was the first gene found to be associated with familial ALS. LÄS MER
4. SOD1 misfolding and aggregation in ALS : in the light of conformation-specific antibodies
Sammanfattning : Mutations in the superoxide dismutase 1 (SOD1) gene are linked to the progressive neurodegenerative disease amyotrophic lateral sclerosis (ALS). ALS-associated mutations affect the stability of the SOD1 protein and promote its unfolding. As a consequence, disordered SOD1 species can misfold and accumulate into insoluble aggregates. LÄS MER