Sökning: "caveolin"

Visar resultat 31 - 35 av 38 avhandlingar innehållade ordet caveolin.

  1. 31. Putting the pieces together : elucidation of podocyte biology in the homeostasis of the kidney filtration barrier

    Författare :Patricia M Rodriguez Rivera; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : End-stage renal disease (ESRD) is a devastating condition that can only be treated with chronic dialysis or kidney transplantation. ESRD treatment costs account for up to 10% of healthcare budgets in the Western world. The 5-year survival for patients in dialysis is only about 40%. Glomerular disease processes are the main cause of ESRD. LÄS MER

  3. 32. Improved heart failure care organization including studies of diagnosis, risk prediction and biomarkers in heart failure with preserved ejection fraction

    Författare :Dmitri Matan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Heart failure (HF) is a prevalent condition with low quality of life, high morbidity and mortality, and high societal costs. HF can be divided according to left ventricular ejection fraction (EF) into HF with reduced (HFrEF) or preserved EF (HFpEF). Diagnosis of HFpEF is more complex than for HFrEF. LÄS MER

  4. 33. Basis for reclassification of nasopharyngeal carcinoma

    Författare :Jian-Yong Shao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Nasopharyngeal carcinoma (NPC) shows broad differences in racial and geographical distribution, radiosensitivity, and a multifactorial etiology. This thesis aims to identify molecular biomarkers with potentially valuable for prognostic implications in NPC. LÄS MER

  5. 34. Involvement of lipid rafts in G protein-coupled monoamine receptor trafficking and signaling : a pharmacological approach

    Författare :Benita Sjögren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The present work focused on lipid raft-mediated modulation of signaling and trafficking of serotonin (5-HT) and dopamine receptors. The 5-HT system is one of the most complex neurotransmitter systems, with a wide distribution both in the CNS and in the periphery. LÄS MER

  7. 35. Aniridia-related keratopathy : structural changes, signaling pathways and clinical aspects

    Författare :André Vicente; Fatima Pedrosa Domellöf; Berit Byström; Luis Abegão Pinto; Jing-Xia Liu; Anders Ivarsen; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; aniridia; aniridia-related keratopathy; PAX6; keratoplasty; fetal cornea; Notch1; Wnt; sonic hedgehog; mTOR; keratocyte; oftalmiatrik; ophthalmology;

    Sammanfattning : Aniridia is a congenital autosomal dominant, bilateral, panocular condition, caused by haploinsufficiency of the Pax6 transcription factor. Aniridia-related keratopathy (ARK) significantly affects vision and quality of life in these patients. LÄS MER