Sökning: "carcinoid syndrome"
Visar resultat 1 - 5 av 10 avhandlingar innehållade orden carcinoid syndrome.
1. Midgut carcinoid tumours - biochemical and therapeutic aspects
Sammanfattning : The biology of human midgut carcinoid tumour was studied experimentally in primary cell culture and clinically in patients with the midgut carcinoid syndrome. In cell cultures, tumour cells had a secretory pattern of 5-HTP, 5-HT and 5-HIAA specific for each tumour indicating individual regulation of synthesis/degradation. LÄS MER
2. Tumour Biological Factors Characterizing Metastasizing Serotonin-producing Ileocaecal Carcinoids
Sammanfattning : In this study, metastasizing serotonin-producing ileocaecal carcinoid tumours (MSPCs) were examined for biological characteristics that could be used to define clinically relevant subgroups within this patient population. Possible targets for new treatment options were also explored. LÄS MER
3. Towards Immunotherapy of Midgut Carcinoid Tumors
Sammanfattning : Classical midgut carcinoids belong to neuroendocrine tumors of the gastroenteropancreatic tract (GEP-NETs) and are associated with serotonin overproduction. The term midgut is derived from the tumors’ embryological site of origin: enterochromaffin cells in the lower jejunum, ileum, caecum and the ascending colon. LÄS MER
4. Molecular studies of endocrine tumors : Insights from genetics and epigenetics
Sammanfattning : Endocrine tumors may be benign or malignant and may occur in any of the hormone producing tissues. They share several biological characteristics, including a low mutation-burden, and may co-occur in several hereditary tumor syndromes. The aim of this thesis was to identify genetic and epigenetic aberrations in endocrine tumors. LÄS MER
5. Towards a bacterial origin of irritable bowel syndrome
Sammanfattning : Background: The irritable bowel syndrome (IBS) is one of the most prevalent disorders and affects about 15% of the Swedish population. Patients with IBS suffer from abdominal pain and disturbed bowel function. Despite being so common, little is known about causality in IBS. LÄS MER