Sökning: "c-myc"

Visar resultat 16 - 20 av 90 avhandlingar innehållade ordet c-myc.

  1. 16. Structure and function in c-Myc and Grx4 : two key proteins involved in transcriptional activation and oxidative stress

    Författare :Malin Fladvad; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The proto-oncogene c-myc is critical for growth and development and deregulation of c-myc expression affects the initiation and expansion of a wide range of human cancers, many of them aggressive. cMyc is a multi-domain protein, where it's C-terminal basic helix-loop-helix leucine zipper (bHLH-Zip) domain heterodimerizes with Max to accomplish gene regulatory activity. LÄS MER

  3. 17. Studies of myc gene expression and a novel endoribonuclease activity

    Författare :Anders Wennborg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :c-myc; B-myc; heat-shock; mRNA degradation; endoribonucleases; AUUUAmotifs; RNase E.;

    Sammanfattning : The general aim of this work was to study the regulation of cellular oncogene expression, with emphasis on the c-myc gene, which is de-regulated in several human and animal tumors. The steady-state expression level of c-myc mRNA or protein was analyzed in panels of human Blymphoid cell lines with different growth and transformation properties, and the general observation was a co-variation between high c-myc expression and a more malignant phenotype of the cell lines. LÄS MER

  4. 18. Molecular factors relevant to the radiosensitivity of human tumours

    Författare :Anya Polischouk; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :c-Ha-ras; c-myc; radiosensitivity; DNA double-strand break repair; DNA singlestrand repair;

    Sammanfattning : Oncogenes, activated copies of normal cellular genes, are involved in carcinogenesis and have been suggested to be determinants of cellular radiosensitivity (RS). Mutations and gene rearrangement of c-Ha-RAS and c-MYC oncogenes were analysed in 70 biopsies and 51 blood samples from the same patients and compared with RS estimated by the clinical tumour response and by response to irradiation of tumour samples using subrenal capsule assay. LÄS MER

  5. 19. Ribosome biogenesis during skeletal muscle hypertrophy

    Författare :Ferdinand von Walden; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Muscle adaptation to chronic resistance exercise (RE) is the result of a cumulative effect on gene expression and protein content. Following a bout of RE, muscle protein synthesis increases and, if followed by consecutive bouts (training), protein accretion and muscle hypertrophy develops. LÄS MER

  7. 20. The role of androgen in prostate cancer cell invasion

    Författare :Yin-Choy Chuan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Prostate cancer (PCa) is the most commonly diagnosed cancer in men in developed countries. Androgen deprivation therapy (ADT) is the mainstay treatment for patient diagnosed with PCa. However, the cancer will eventually relapse with metastatic cancer and become resistant to the treatment. LÄS MER