Sökning: "DNA singlestrand repair"
Hittade 2 avhandlingar innehållade orden DNA singlestrand repair.
1. Molecular factors relevant to the radiosensitivity of human tumours
Sammanfattning : Oncogenes, activated copies of normal cellular genes, are involved in carcinogenesis and have been suggested to be determinants of cellular radiosensitivity (RS). Mutations and gene rearrangement of c-Ha-RAS and c-MYC oncogenes were analysed in 70 biopsies and 51 blood samples from the same patients and compared with RS estimated by the clinical tumour response and by response to irradiation of tumour samples using subrenal capsule assay. LÄS MER
2. Modulation of activity of the tumour suppressor p53 by small molecules and damaged DNA
Sammanfattning : The p53 is a potent tumor suppressor, which becomes activated in response to stress. The activated p53 triggers a cell cycle arrest in GI or apoptosis, ensuring a suppression of a tumor development by the elimination of cells carrying potentially tumorigenic lesions. LÄS MER