Sökning: "bone marrow stem cells"

Visar resultat 21 - 25 av 176 avhandlingar innehållade orden bone marrow stem cells.

1. 21. Cellular and Molecular Pathways Governing Hematopoietic Stem Cell Fate

   Författare :Liping Yang; Stamcellscentrum (SCC); []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; stem cell; hematopoiesis; bone marrow transplantation; lineage commitment; cytokine; Medicine human and vertebrates ; Clinical genetics; Klinisk genetik; extracellulära vätskor; Hematologi; Medicin människa och djur ; extracellular fluids; Haematology;

   Sammanfattning : Hematopoietic Stem Cells (HSCs) have been defined to have abilities of both self-renewal and multi-lineage differen-tiation. The balance between these abilities is rigorously controlled under steady-state status (homeostasis) and when the normal processes of self-renewal and differentiation become deregulated, a disorder of blood system (such as leukemias) can occur. LÄS MER

3. 22. Regulation of normal and cancer cells as a base for cell cycle-targeted therapy

   Författare :Regina Miftakhova; Malmö Experimentell cancerforskning; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell cycle regulation; cyclin A1; stem cells; stem cell niche; epigenetics; cancer;

   Sammanfattning : The majority of current treatments used for treatment of prostate cancer (PCa) and leukemia are often limited to a narrow subsets of treated patients. As such, there still remains a significant scope for gaining deeper understanding of molecular mechanisms underlying cancer metastasis for improvement of targeted treatment. LÄS MER

4. 23. Investigations of Hematopoietic Stem Cells and Their Age-Associated Alterations

   Författare :Alexandra Rundberg Nilsson; Avdelningen för molekylär hematologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoietic stem cells; Aging; Serial transplantation; Self-renewal; Flow cytometry; Gene expression;

   Sammanfattning : The hematopoietic stem cell (HSC) has and continues to be extensively investigated, and represents by far the most studied somatic stem cell. Development of various experimental technologies, including fluorescence activated cell sorting (FACS), have been crucial for research advancements within the hematopoietic field. LÄS MER

5. 24. THE HYPOXIC HEMATOPOIETIC STEM CELL NICHE Consequences of Hypoxia-induced Transcription on Stem Cell Fate

   Författare :Matilda Rehn; Avdelningen för molekylärmedicin och genterapi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoietic Stem Cells; Stem Cell Niche; Hypoxia; Hypoxia-Inducible Factor; Vegfa.;

   Sammanfattning : Hematopoiesis is the process of blood formation that originates with the hematopoietic stem cell (HSC), a cell type that is responsible for the life-long supply of mature blood cells. HSCs are defined by their ability to self-renew as well as giving rise to differentiated cells of all blood lineages. LÄS MER

7. 25. Characterisation of human fetal mesenchymal stem cells

   Författare :Cecilia Götherström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Mesenchymal stem cells; fetal stem cell transplantation; intrauterine transplantation; osteogenesis imperfecta; mixed lymphocyte culture; gene array;

   Sammanfattning : Mesenchymal stem cells (MSCs) are present in various tissues of fetal and adult origin. I isolated and expanded MSCs from human fetal 1st trimester livers and observed that they have a shorter cell doubling time compared to adult bone marrow-derived MSCs. LÄS MER