Sökning: "bioluminescence."

Visar resultat 11 - 15 av 29 avhandlingar innehållade ordet bioluminescence..

  1. 11. Dissemination of Toxoplasma gondii to the central nervous system : with special reference to in vivo bioluminescence imaging

    Författare :Isabel Dellacasa Lindberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Toxoplasma gondii causes an asymtomatic chronic infection in immune competent individuals that can be life-threatening in individuals that become immuno-compromised or to the developing fetus. This thesis aimed to (1) establish a novel murine model to study acute and reactivated toxoplasmosis in real-time using in vivo bioluminescence imaging (BLI), (2) investigate the migratory pathways utilized by Toxoplasma for systemic dissemination, especially to the central nervous system (CNS) and (3) address the role of resident brain glia cells in the setting of recrudescent infection in mice. LÄS MER

  2. 12. Expression of multidrug resistance genes and proteins and effect of selenite in anthracycline-resistant human tumor cell lines

    Författare :Kerstin Jönsson Videsäter; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Multidrug resistance; cross-resistance profile; ATP-bioluminescence assay; pglycoprotein; MRP1; selenium; thioredoxin reductase; glutathione reductase.;

    Sammanfattning : Treatment failure due to development of drug resistance is a serious complication in cancer treatment and the major cause of death in these patients. This thesis has focused on to gain knowledge about the mechanisms of multidrug resistance and to establish in vitro methods to characterize the resistant tumor cell phenotype. LÄS MER

  3. 13. Microbial factors and host responses affecting severity of pneumococcal disease and pneumococcal carriage

    Författare :Andreas Sandgren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Streptococcus pneumoniae; molecular epidemiology; serotype; clonality; clones; antibiotic resistance; virulence; animal model; mice; innate immunity; Toll-like receptors; MyD88; bioluminescence.;

    Sammanfattning : Streptococcus pneumoniae, also known as the pneumococcus, is a human specific bacterium and causes infections like otitis media, sinusitis, pneumonia, sepsis and meningitis. However, these bacteria are also frequent colonizers of the nasopharynx of healthy individuals, especially children. LÄS MER

  4. 14. Pharmacodynamic effects of antibiotics : studies on bacterial morphology, initial killing, postantibiotic effect and effecitive regrowth time

    Författare :Håkan Hanberger; Otto Cars; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Pharmacodynamics of antibiotics deals with time course of drug activity and mechanisms of action of drugs on bacteria. In this thesis pharmacodynamic parameters have been studied after brief exposure of gram-positive bacteria to daptomycin, imipenem or vancomycin and after short exposure of gram-negative bacteria to amikacin, ampicillin, aztreonam, cefepime, cefotaxime, ceftazidime, ceftriaxone, cefuroxime, imipenem, mecillinal,11, or piperacillin. LÄS MER

  5. 15. Luminescent textiles using biobased products : A bioinspired approach

    Författare :Sweta Iyer; Högskolan i Borås; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; bioinspired; biobased; bioluminescent; photoluminescent; textile; luminous bacteria; enzymes; immobilization; plasma; riboflavin; flavin mononucleotide; sustainable; digital printing; functionalization; Textil och mode generell ; Textiles and Fashion General ;

    Sammanfattning : Nature has designed a few biobased molecules that are responsible for bioluminescence and photoluminescence in some living species. In this thesis, the potential use of luminescence phenomena existing in nature toward the attainment of luminescent textiles was explored. LÄS MER