Sökning: "beta-catenin"

Visar resultat 21 - 25 av 27 avhandlingar innehållade ordet beta-catenin.

  1. 21. Signaling via the bHLH-PAS proteins AhR and HIF

    Författare :Cecilia Bosdotter; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This thesis concerns some mechanistic properties of the basic helix-loop-helix/PAS (bHLH-PAS) factors aryl hydrocarbon receptor (AhR) and hypoxia-inducible factor 1 alpha (HIF-1α). The bHLH-PAS family of proteins is a family of factors that controls a variety of developmental and physiological events. LÄS MER

  3. 22. Different genetic pathways involved in colorectal cancer

    Författare :Sima Salahshor; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Colorectal cancer (CRC) is one of the three leading causes of cancer mortality worldwide with an incidence of approximately one million cases and a mortality of 500 000 annually. Identification of different pathways involved in tumorigenesis of both familial and sporadic colorectal cancer may led to a major breakthrough in the prevention of this potentially curable disease. LÄS MER

  4. 23. Integrin-interacting proteins in human cancer progression

    Författare :Zhengwen An; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Integrins are the major transmembrane receptors for the extracellular matrix (ECM) which regulate a diverse array of cellular functions crucial to tumor cell migration, invasion, proliferation and survival. Integrins contact the ECM via their N-terminal extracellular domains and connect to the intracellular environment via the C-terminal cytoplasmic domains. LÄS MER

  5. 24. Differential expression pattern of CEACAM1 isoforms in polarized epithelial cells : it's regulation and some functional consequences

    Författare :Ulla Sundberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :CEACAM1; adhesion; lateral localization; adherens junctions; desmosomes; primary cilia;

    Sammanfattning : The cell adhesion molecule CEACAM1 is expressed in epithelia, small vessel endothelia and leukocytes as two major, co-expressed isoforms, CEACAM1-L and CEACAM1-S, which differ in their cytoplasmic domains. CEACAM1 has been found both in cell-cell contact areas and on apical surfaces of polarized epithelial cells. LÄS MER

  7. 25. Molecular genetic studies on genes involved in hereditary nonpolyposis colorectal cancer (HNPCC)

    Författare :Tao Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :colorectal cancer; endometrial cancer; HNPCC; mismatch repair genes; bhMSH2; hMLH1; hPMS1; hPMS2; hMSH6; mutation screening; MSI; LOH.;

    Sammanfattning : Colorectal cancer (CRC) is a major public health problem in Western countries, and it is the third leading cause of death from cancer in both males and females. Inherited predisposition can be divided into two subgroups based on the absence or the presence of multiple benign colorectal polyps. LÄS MER