Sökning: "beta-catenin"
Visar resultat 11 - 15 av 27 avhandlingar innehållade ordet beta-catenin.
11. Wnt-5a Signalling in Human Mammary Cells: Implications for the Development of Breast Cancer
Sammanfattning : The Wnt-5a gene encodes a secreted protein that regulates several normal processes in embryonic and adult tissues by as yet unknown mechanisms. Expression of Wnt-5a protein does not cause cell transformation, but it instead counteracts the effects induced by transforming Wnts. LÄS MER
12. Pivotal role of the nuclear receptor PPARgamma in colon epithelial cells
Sammanfattning : When symbiosis between the residential intestinal flora and the epithelial cells of the gastrointestinal tract is broken one endpoint may be chronic inflammation, e.g. Inflammatory Bowel Disease (IBD). The disruption of the epithelial lining elicits activation of NF-kappaB and secretion of potent inflammatory mediators. LÄS MER
13. New potential targets in medulloblastoma therapy : studies on cellular mechanisms and mediators
Sammanfattning : Medulloblastoma is an embryonal tumour that mainly affects children. It is the most common malignant brain tumour in children and accounts for 15% of all childhood brain tumours. It most often presents in the cerebellum and is considered to be a disorder of normal development. LÄS MER
14. Aniridia-related keratopathy : structural changes, signaling pathways and clinical aspects
Sammanfattning : Aniridia is a congenital autosomal dominant, bilateral, panocular condition, caused by haploinsufficiency of the Pax6 transcription factor. Aniridia-related keratopathy (ARK) significantly affects vision and quality of life in these patients. LÄS MER
15. p63 and potential p63 targets in squamous cell carcinoma of the head and neck
Sammanfattning : Squamous cell carcinoma of the head and neck (SCCHN), the 6th most common cancer worldwide, has a low 5-year survival. Disease as well as treatment often causes patients severe functional and aesthetic problems. LÄS MER