Sökning: "autologous stem cell transplantation"

Visar resultat 21 - 25 av 37 avhandlingar innehållade orden autologous stem cell transplantation.

1. 21. Immunoglobulin Gene Analysis in Different B cell Lymphomas : With Focus on Cellular Origin and Antigen Selection

   Författare :Mia Thorsélius; Richard Rosenquist Brandell; Christer Sundström; Anders Rosén; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; B cell lymphoma; Immunoglobulin; V gene; somatic hypermutation; antigen selection; quantitative PCR; Genetik; Clinical genetics; Klinisk genetik;

   Sammanfattning : B cell lymphoma (BCL) comprises a biologically and clinically heterogeneous group of tumors deriving from different stages of B cell development. The immunoglobulin (Ig) variable heavy chain (VH) gene rearrangement is unique for each BCL and can be used to reveal cellular origin, to study signs of antigen selection and to quantify tumor cell load. LÄS MER

3. 22. Optimization of suicide gene therapy in stem cell transplantation with special reference to the selection marker OuaSelect

   Författare :Alexandra Treschow; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Gene therapy; cell selection; suicide gene; cancer; immunotherapy; viral vectors; thymidine kinase; Na ; K -ATPase;

   Sammanfattning : For many patients suffering from leukemia and other hematological malignancies, allogeneic hematopoietic stem cell transplantation (HSCT) represents the only curative approach. However, an optimal HSCT procedure is yet to be developed. Transplant-related morbidity and mortality are severe complications arising from this treatment modality. LÄS MER

4. 23. B-cell immunity in patients with hematological malignancies and after stem cell transplantation : studies with special reference to tetanus and pneumococcal immunity

   Författare :Viera Hammarström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Treatment of malignancies with cytotoxic chemotherapy and/or bone marrow or stem cell transplantation also suppress the immune system which becomes incapable of controlling infections. Therefore infections can remain a serious problem for an extended period in these patients. LÄS MER

5. 24. Gastro-intestinal toxicity related to haemopoietic stem cell transplantation with a special focus on the intestinal barrier function

   Författare :Jan-Erik Johansson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : The myeloablative, cytotoxic therapy (conditioning treatment) prior to haemopoietic stem cell transplantation (HSCT) has the combined purpose of eliminating leukaemic or cancer cells located in the bone marrow or elsewhere in the body and, in the allogeneic setting, of suppressing the immune response of the recipient to prevent marrow rejection. The unwanted effect is the inevitable elimination of normal, haemopoietic stem cells, a lethal effect which is circumvented by the following administration of haemopoietic stem cells from the patient (autologous HSCT) or from a related or an unrelated donor (allogeneic HSCT). LÄS MER

7. 25. lnduction Therapies in Multiple Sclerosis - Clinical and immunological follow-up

   Författare :Sofia Sandgren; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Multiple Sclerosis; Neurodegeneration; Alemtuzumab; Autologous hematopoietic stem cell transplantation; Induction therapies Immune reconstitution therapies;

   Sammanfattning : Multiple sclerosis (MS) is a chronic disease that damages the central nervous system. Its pathophysiology is complex, and consists of inflammation and degeneration from the disease onset. The treatment of MS has continuously been developed with improved efficacy. LÄS MER