Sökning: "somatic hypermutation"

Visar resultat 1 - 5 av 19 avhandlingar innehållade orden somatic hypermutation.

  1. 1. Analysis of Immunoglobulin Genes and Telomeres in B cell Lymphomas and Leukemias

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Sarah Walsh; Uppsala universitet.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; B cell lymphoma leukemia; mantle cell lymphoma; hairy cell leukemia; lymphoplasmacytic lymphoma; immunoglobulin genes; antigen selection; telomeres; cellular origin; somatic hypermutation; Genetik; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Clinical genetics; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Klinisk genetik;

    Sammanfattning : B cell lymphomas and leukemias are heterogeneous tumors with different cellular origins. Analysis of immunoglobulin (Ig) genes enables insight into the B cell progenitor, as Ig somatic hypermutation correlates with antigen-related B cell transit through the germinal center (GC). LÄS MER

  2. 2. Immunoglobulin Gene Analysis in Different B cell Lymphomas With Focus on Cellular Origin and Antigen Selection

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Mia Thorsélius; Uppsala universitet.; [2004]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; B cell lymphoma; Immunoglobulin; V gene; somatic hypermutation; antigen selection; quantitative PCR; Genetik; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Clinical genetics; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Klinisk genetik;

    Sammanfattning : B cell lymphoma (BCL) comprises a biologically and clinically heterogeneous group of tumors deriving from different stages of B cell development. The immunoglobulin (Ig) variable heavy chain (VH) gene rearrangement is unique for each BCL and can be used to reveal cellular origin, to study signs of antigen selection and to quantify tumor cell load. LÄS MER

  3. 3. Stereotyped B Cell Receptors in Chronic Lymphocytic Leukaemia Implications for Antigen Selection in Leukemogenesis

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Fiona Murray; Uppsala universitet.; [2008]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chronic lymphocytic leukaemia; immunoglobulin genes; somatic hypermutation; stereotyped B cell receptors; antigen selection; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Clinical genetics Molecular biology; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Klinisk genetik Molekylärbiologi;

    Sammanfattning : Biased immunoglobulin heavy variable (IGHV) gene usage and distinctive B-cell receptor (BCR) features have been reported in chronic lymphocytic leukaemia (CLL), which may reflect clonal selection by antigens during disease development. Furthermore, the IGHV gene mutation status distinguishes two clinical entities of CLL, where patients with unmutated IGHV genes have an inferior prognosis compared to those with mutated IGHV genes. LÄS MER

  4. 4. Role of DNA repair in class switch recombination and somatic hypermutation

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Laboratory Medicine

    Författare :Likun Du; Karolinska Institutet.; Karolinska Institutet.; [2011]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Class switch recombination (CSR) and somatic hypermutation (SHM), occurring in the germinal center, are two important processes for B cell development. Both are initiated by activation-induced cytidine deaminase (AID), through deamination of the C residues in the variable and switch regions of the immunoglobulin locus, resulting in either in single stranded or double stranded DNA breaks. LÄS MER

  5. 5. Studies of molecular events during peripheral B cell differentiation

    Detta är en avhandling från Jens Wrammert; BMC I:13; Lund University; 22184 Lund; Sweden

    Författare :Jens Wrammert; Lund University.; Lunds universitet.; [2002]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Immunologi; serologi; serology; Immunology; B cells; Differentiation;

    Sammanfattning : This thesis focuses on molecular changes occuring during terminal B cell differentiation as well as on somatic hypermutation and the generation and maintenance of B cell memory. During T cell dependent immune responses the average affinity for the eliciting antigen increases with time. LÄS MER