Sökning: "antigen selection"

Visar resultat 1 - 5 av 86 avhandlingar innehållade orden antigen selection.

  1. 1. Stereotyped B Cell Receptors in Chronic Lymphocytic Leukaemia : Implications for Antigen Selection in Leukemogenesis

    Författare :Fiona Murray; Richard Rosenquist Brandell; Kostas Stamatopoulos; Gunilla Enblad; Gerard Tobin; Manlio Ferrarini; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chronic lymphocytic leukaemia; immunoglobulin genes; somatic hypermutation; stereotyped B cell receptors; antigen selection; Molecular biology; Molekylärbiologi;

    Sammanfattning : Biased immunoglobulin heavy variable (IGHV) gene usage and distinctive B-cell receptor (BCR) features have been reported in chronic lymphocytic leukaemia (CLL), which may reflect clonal selection by antigens during disease development. Furthermore, the IGHV gene mutation status distinguishes two clinical entities of CLL, where patients with unmutated IGHV genes have an inferior prognosis compared to those with mutated IGHV genes. LÄS MER

  3. 2. Immunoglobulin Gene Analysis in Different B cell Lymphomas : With Focus on Cellular Origin and Antigen Selection

    Författare :Mia Thorsélius; Richard Rosenquist Brandell; Christer Sundström; Anders Rosén; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; B cell lymphoma; Immunoglobulin; V gene; somatic hypermutation; antigen selection; quantitative PCR; Genetik; Clinical genetics; Klinisk genetik;

    Sammanfattning : B cell lymphoma (BCL) comprises a biologically and clinically heterogeneous group of tumors deriving from different stages of B cell development. The immunoglobulin (Ig) variable heavy chain (VH) gene rearrangement is unique for each BCL and can be used to reveal cellular origin, to study signs of antigen selection and to quantify tumor cell load. LÄS MER

  4. 3. Selection of antigens for antibody-based proteomics

    Författare :Lisa Berglund; Mathias Uhlén; Sören Brunak; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; epitope; antigen; antibody; affinity; protein; proteome; proteomics; bioinformatics; prediction; primer design; sequence similarity; Bioengineering; Bioteknik;

    Sammanfattning : The human genome is predicted to contain ~20,500 protein-coding genes. The encoded proteins are the key players in the body, but the functions and localizations of most proteins are still unknown. LÄS MER

  5. 4. Selection and design in antibody phage display

    Författare :Jonas Persson; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; specificity fine-tuning.; phage display; MUC1; automated selection; antigenicity; antibody; affinity maturation;

    Sammanfattning : The immune system is an important part of the physiology of higher organisms. In the immune system antibodies play a key role in neutralizing and clearing potentially lethal threats from the environment. The importance of antibodies in the immune system has made them come to the attention as a tool in chemistry and medicine. LÄS MER

  7. 5. Molecular Recognition in Antibody Engineering. Studies on recombinant and phage displayed antibodies

    Författare :Ann-Christin Malmborg Hager; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; affinity; antibody; kinetic; Immunologi; serologi; serology; Immunology; Bioteknik; Biotechnology; library; selection; surface display; phage display; association rate; dissociation rate;

    Sammanfattning : In vitro generation of antibody fragments of desired specificity and affinity plays an important role since it permits the generation of reagents which may be valuable for diagnostic and therapeutic applications. Furthermore, the kinetic parameters for an antibody-antigen interaction, rather than the affinity, has shown to correlate with biological functions like virus neutralization. LÄS MER