Sökning: "antimalarials"

Visar resultat 11 - 15 av 25 avhandlingar innehållade ordet antimalarials.

  1. 11. Exploring malaria case mangement of underfive children at households and public primary health care facilities in Kibaha district, Tanzania

    Författare :Stephen E D Nsimba; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Malaria; underfive children; chloroquine; sulfadoxine pyrimethamine; case management; mothers guardians; households; public health care facilities; Tanzania;

    Sammanfattning : Background: Chloroquine (CQ) was the first line drug for treating malaria in Tanzania until 2001 when it was replaced with sulfadoxine/pyrimethamine (SP). The first four studies (I -IV) were conducted before the policy change, and the last one (V) after. LÄS MER

  3. 12. Clinical Pharmacokinetics of the Antimalarial Artemisinin Based on Saliva Sampling

    Författare :Toufigh Gordi; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Artemisinin; pharmacokinetics; saliva; HPLC; pharmacodynamics; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Biopharmaceutics; biofarmaci;

    Sammanfattning : Artemisinin is the parent compound of a novel family of antimalarials. Repetitive administrations of artemisinin to both healthy volunteers and malaria patients have been shown to result in decreased plasma concentrations of the compound, most probably due to an autoinduction of different CYP450 enzymes. LÄS MER

  4. 13. Piperaquine and Metabolites - Bioanalysis and Pharmacokinetics

    Författare :Mohd Yusmaidie Aziz; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bioanalysis; Pharmacokinetics; Piperaquine; Malaria;

    Sammanfattning : Antimalarial piperaquine (PQ) is currently used as a partner drug with dihydroartemisinin (DHA), exhibiting high cure rates (>95%) for P. falciparum. Despite its raising usage worldwide with DHA, PQ is synthetically developed outside of big pharma pipelines. LÄS MER

  5. 14. Plasmodium falciparum drug transporter genes in emerging malaria multidrug resistance

    Författare :Maria Isabel Mendes Veiga; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Malaria is caused by an intracellular protozoan parasite of the genus Plasmodium. The use of chemotherapy, the foremost tool available for the control of the disease, has been challenged in the last decades by the development and spread of drug resistance among malaria parasites. LÄS MER

  7. 15. Plasmodium falciparum response to chloroquine and artemisinin based combination therapy (ACT) in Guinea-Bissau

    Författare :Johan Ursing; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Plasmodium falciparum causes the most severe form of malaria and is the most common malaria species in sub-Saharan Africa. Chloroquine used to be the most common drug for the treatment of malaria. Due to development of resistance, chloroquine is no longer efficacious in most of the world. The first line option for treatment of P. LÄS MER