Sökning: "adenoviruses"

Visar resultat 16 - 20 av 39 avhandlingar innehållade ordet adenoviruses.

  1. 16. The quest for new improved adenovirus gene therapy vectors against glioma tumours

    Författare :Johan Skog; Göran Wadell; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gene therapy; virology; adenovirus; glioma; glioblastoma; Genterapi; virologi; adenovirus; gliom; glioblastom; Virology; Virologi;

    Sammanfattning : Gene therapy has received much attention the last decade as a method to correct a number of disorders arising from a defective gene. Gene therapy can be defined as the introduction of a functional genetic element into a cell for a therapeutic purpose. LÄS MER

  3. 17. Adenovirus species B: receptors, tropism and hematopoietic cells

    Författare :Anna Segerman; Göran Wadell; Ya-Fang Mei; Urs Greber; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microbiology; Adenovirus; Species B; hematopoietic; Mikrobiologi; Microbiology; immunology; infectious diseases; Mikrobiologi; immunologi; infektionssjukdomar; medicinsk virologi; Medical Virology;

    Sammanfattning : At present, the human adenoviruses (Ads) comprise 51 members, which have been classified into six species (A to F). In general, adenovirus (Ad) tissue tropism or disease patterns vary according to species, although adenoviruses from different species can sometimes cause the same symptoms. LÄS MER

  4. 18. Genetic re-targeting and de-targeting of adenovirus type 5 in order to create vectors for gene therapy

    Författare :Susanna Myhre; Göteborgs universitet; []
    Nyckelord :Adenovirus; gene therapy; vector; re-targeting; de-targeting; fiber; pIX; affibody molecule; single chain antibody;

    Sammanfattning : Gene therapy has been considered to be a revolutionary development in medicine, whereby the cause and not the symptoms of the disease would be treated. These expectations have as yet not been realized, mainly due to lack of suitable vectors. LÄS MER

  5. 19. The Interaction of the Adenovirus E1B-55K Protein with a Histone Deacetylase Complex: Its Importance in Regulation of P53 Protein Functions

    Författare :Tanel Punga; Göran Akusjärvi; Klas G. Wiman; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; adenovirus; E1B-55K; p53; histone acetylation; Sin3; Biokemi; Biochemistry; Biokemi;

    Sammanfattning : The human tumour suppressor protein p53 is an effective inhibitor of cell growth, by inducing cell cycle arrest and apoptosis. However, p53-induced cell growth inhibition can be detrimental for virus multiplication. Therefore, viruses encode for proteins, which can interfere with the functions of the p53 protein. LÄS MER

  7. 20. Advances in Bone Tissue Engineering

    Författare :Björn Schönmeyr; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Bone deficiencies, caused by malformations, trauma or adverse effects from medical treatments, are a clinical challenge and often associated with reduced physical function and quality of life. Autologeous bone grafts can be used to reconstruct skeletal defects, but the right size and quality of bone might not always be available and even so, donor-site morbidity might follow. LÄS MER