Sökning: "re-targeting"

Hittade 3 avhandlingar innehållade ordet re-targeting.

1. 1. Genetic re-targeting and de-targeting of adenovirus type 5 in order to create vectors for gene therapy

   Författare :Susanna Myhre; Göteborgs universitet; []
   Nyckelord :Adenovirus; gene therapy; vector; re-targeting; de-targeting; fiber; pIX; affibody molecule; single chain antibody;

   Sammanfattning : Gene therapy has been considered to be a revolutionary development in medicine, whereby the cause and not the symptoms of the disease would be treated. These expectations have as yet not been realized, mainly due to lack of suitable vectors. LÄS MER

3. 2. Genetic re-targeting of adenoviral vectors for gene therapy applications

   Författare :Maria K Magnusson; Göteborgs universitet; []
   Nyckelord :;

   Sammanfattning : The adenovirus (Ad) is a frequent cause of upper respiratory tract infections, enteritis and conjunctivitis. Since its first isolation in 1953, the study of Ad has contributed greatly to the understanding of intracellular events and has also served as a model system for many viruses. LÄS MER

4. 3. Targeting molecular mechanisms for epigenetic silencing in multiple myeloma : Implications for biology and precision medicine

   Författare :Patrick Nylund; Helena Jernberg Wiklund; Antonia Kalushkova Nair; Fredrik Öberg; Toril Holien; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Multiple myeloma; epigenetics; PRC2; lncRNA; metabolomics; miRNA.;

   Sammanfattning : Multiple myeloma (MM) is a heterogeneous haematological cancer where malignant plasma cells clonally expand within the bone marrow. The transcriptional repressor PRC2 and its catalytic subunit EZH2 play a major role in MM, as PRC2 re-targeting results in a MM-specific gene silencing profile. LÄS MER