Sökning: "adenoviruses"

Visar resultat 11 - 15 av 39 avhandlingar innehållade ordet adenoviruses.

  1. 11. Design and Synthesis of Sialic Acid Conjugates as Inhibitors of EKC-causing Adenoviruses

    Författare :Susanne Johansson; Jan Kihlberg; Mikael Elofsson; Stefan Oscarson; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Sialic acid; sialylmimetics; sialylation; multivalency; glycoconjugates; adenovirus; antiviral agents; epidemic keratoconjunctivitis; Bioorganic chemistry; Bioorganisk kemi;

    Sammanfattning : The combat against viral diseases has been, and still is, a major challenge in the field of drug development. Viruses are intracellular parasites that use the host cell ma-chinery for their replication and release. Therefore it is difficult to target and destroy the viral particle without disturbing the essential functions of the host cell. LÄS MER

  3. 12. Enteric adenovirus type 41 : genome organization and specific detection procedures

    Författare :Annika Allard; Göran Wadell; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; EAd Ad41 EIA E1B detection PCR;

    Sammanfattning : Enteric adenoviruses (EAd) types 40 and 41 (Ad40 and Ad41) representing subgenus F, are primary pathogens of children being second only to rotaviruses as the most important cause of infantile diarrhea.The EAds differ from all other adenoviruses in their inability to grow in most conventional established cell lines and have been suggested to be deficient in some early gene functions since they could be complemented by Ad 5 early regions EIA and E1B. LÄS MER

  4. 13. Adenoviral small non-coding RNAs : A Structural and Functional Charaterization

    Författare :Wael Kamel; Göran Akusjärvi; Ben Berkhout; Uppsala universitet; []
    Nyckelord :non-coding RNA miRNA mivaRNA canonical Dicer Ago2 TSS m7G Cap Adenovirus replication E2B;

    Sammanfattning : Since their discovery in 1953, adenoviruses have significantly contributed to the understanding of virus-host cell interactions, including mechanistic details of cellular processes such as cell cycle control and alternative RNA splicing. Among the first characterized adenoviral genes were the virus-associated RNAs (VA RNAI/II), which are produced in massive amount during a lytic infection. LÄS MER

  5. 14. Replication-competent adenovirus 11p vector as a new oncolytic agent

    Författare :Jim Silver; Ya-Fang Mei; Gunnel Halldén; Umeå universitet; []
    Nyckelord :Virologi; Adenovirus; Vector; mikrobiologi; Microbiology;

    Sammanfattning : Human adenoviruses (Ads) as vectors have been studied for cancer gene therapy for several decades due to their ability to shut down host cell replication and lyse tumour cells. Ad5 of species C is commonly used as a replication-defective or a replication-competent vector. LÄS MER

  7. 15. Adenovirus species B interactions with CD46

    Författare :Dan Gustafsson; Ya-Fang Mei; Urs Greber; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Adenovirus 11; CD46; mikrobiologi; Microbiology;

    Sammanfattning : Adenoviruses (Ad) are double-stranded (ds) DNA, non-enveloped viruses. There are seven species (A-G) of human Ads with 52 knownserotypes to date. Human Ads cause a broad range of pathologies, ranging from upper respiratory tract infections to persistent urinary tract infections. LÄS MER